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dpr11 defective proboscis extension response 11 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40800, updated on 9-Dec-2024

Summary

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Official Symbol
dpr11provided by FlyBase
Official Full Name
defective proboscis extension response 11provided by FlyBase
Primary source
FLYBASE:FBgn0053202
Locus tag
Dmel_CG33202
See related
AllianceGenome:FB:FBgn0053202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH22307; CG15181; CG15182; CG15183; CG31309; CG33202; CT35098; Dmel\CG33202; Dpr-11; Dpr11
Summary
Involved in establishment of synaptic specificity at neuromuscular junction; photoreceptor cell axon guidance; and regulation of neuromuscular junction development. Located in neuron projection membrane. Is expressed in cell body rind of adult medulla; larval ventral nerve cord; medulla layer; and photoreceptor cell R7. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See dpr11 in Genome Data Viewer
Location:
83F1-83F4; 3-47.5 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6529169..6593330, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2354891..2419052, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene transfer RNA:Methionine-CAT 1-5 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46132 Neighboring gene PFTAIRE-interacting factor 2 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Sancer G, et al. Arthropod Struct Dev, 2021 Mar. PMID 33618155
  2. Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia. Smoyer LK, et al. Genet Res, 2003 Dec. PMID 15134195
  3. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article
  4. Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits. Menon KP, et al. Elife, 2019 Nov 6. PMID 31692445, Free PMC Article
  5. Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits. Xu S, et al. Neuron, 2018 Dec 19. PMID 30467079, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions between Dpr11 and DIP-gamma control selection of amacrine neurons in Drosophila color vision circuits.
    Title: Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits.
  2. study provides evidence that DIPgamma in yDm8 neurons and Dpr11 in yR7 photpreceptors instruct synaptic partner matching
    Title: Coordination between stochastic and deterministic specification in the Drosophila visual system.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in establishment of synaptic specificity at neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in photoreceptor cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
defective proboscis extension response 11
Names
CG33202-PB
CG33202-PC
dpr11-PB
dpr11-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6529169..6593330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275391.1 → NP_001262320.1  defective proboscis extension response 11, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRE6, Q9VI28
    Conserved Domains (4) summary
    smart00408
    Location:234 → 311
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:227 → 320
    IG_like; Immunoglobulin like
    pfam07679
    Location:125 → 216
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:127 → 217
    Ig; Immunoglobulin domain

  2. NM_176409.2 → NP_788586.1  defective proboscis extension response 11, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRE6, Q9VI28
    Related
    FBpp0081202
    Conserved Domains (4) summary
    smart00408
    Location:234 → 311
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:227 → 320
    IG_like; Immunoglobulin like
    pfam07679
    Location:125 → 216
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:127 → 217
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MRE6 Q8MRE6

Gene LinkOut

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