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Taf1 TBP-associated factor 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40813, updated on 9-Dec-2024

Summary

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Official Symbol
Taf1provided by FlyBase
Official Full Name
TBP-associated factor 1provided by FlyBase
Primary source
FLYBASE:FBgn0010355
Locus tag
Dmel_CG17603
See related
AllianceGenome:FB:FBgn0010355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS00004.13; cel; cell; CG17603; d230; Dmel\CG17603; dmTAF1; dmTAF[[II]]230; dTAF1; dTAF230; dTAF250; dTAFII250; dTAF[[II]]230; dTAF[[II]]250; EfW1; l(3)84Ab; p230; SR3-5; TAF; taf1; TAF1; Taf1p; Taf200; TAF200; Taf230; TAF230; Taf250; TAF250; TAF250/230; TAFII-250; TAFII250; TAF[II]250; TAF[[II]]; TAF[[II]]230; Taf[[II]]250; TAF[[II]]250; TAF[[II]]250/230; TFIID; TFIID TAF250
Summary
Enables several functions, including histone acetyltransferase activity; ubiquitin activating enzyme activity; and ubiquitin conjugating enzyme activity. Contributes to RNA polymerase II general transcription initiation factor activity. Involved in RNA polymerase II preinitiation complex assembly. Located in nucleolus and nucleoplasm. Part of transcription factor TFIID complex. Is expressed in several structures, including embryonic/larval midgut; ganglia; male germline cell; and testis. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1L (TATA-box binding protein associated factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Taf1 in Genome Data Viewer
Location:
84A1-84A1; 3-48 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6646889..6656048)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2472611..2481770)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene sungrazer Neighboring gene uncharacterized protein Neighboring gene Argininosuccinate synthase Neighboring gene uncharacterized protein Neighboring gene twisted bristles roughened eye Neighboring gene O-6-alkylguanine-DNA alkyltransferase Neighboring gene labial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. Liu D, et al. Cell, 1998 Sep 4. PMID 9741622
  2. Regulation of gene expression by TBP-associated proteins. Lee TI, et al. Genes Dev, 1998 May 15. PMID 9585500
  3. Drosophila TAF(II)230 and the transcriptional activator VP16 bind competitively to the TATA box-binding domain of the TATA box-binding protein. Nishikawa J, et al. Proc Natl Acad Sci U S A, 1997 Jan 7. PMID 8990165, Free PMC Article
  4. TATA box mimicry by TFIID: autoinhibition of pol II transcription. Burley SK, et al. Cell, 1998 Sep 4. PMID 9741619
  5. Transcriptional activation is weakened when Taf1p N-terminal domain 1 is substituted with its Drosophila counterpart in yeast TFIID. Kasahara K, et al. Genes Genet Syst, 2019 Apr 9. PMID 30905891

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAF1 is involved in both establishing an upper limit of transcription during induction and efficiently turning the gene off once the inducer is removed
    Title: Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
  2. The existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, is shown.
    Title: Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex.
  3. TAF1 pre-mRNA elements identified in this study are independently targeted by developmental signaling pathways to result in tissue-specific inclusion of exon 12a and/or 13a.
    Title: A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing.
  4. results suggest stepwise assembly of a testis-specific TFIID complex (tTFIID) whereby a TAF1 isoform, presumably TAF1-2, is recruited to a core subassembly of tTAFs in spermatocyte nucleoli
    Title: Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K14 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin activating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
TBP-associated factor 1
Names
CG17603-PA
CG17603-PB
CG17603-PC
CG17603-PD
CG17603-PE
CG17603-PF
TATA-associated factor 250
TBP-associated factor
TBP-associated factor 250
TBP-associated factor 250kD
TFIID 230 kda subunit
Taf1-PA
Taf1-PB
Taf1-PC
Taf1-PD
Taf1-PE
Taf1-PF
cell lethal
suppressor of Ras85D 3-5
NP_001163532.1
NP_001246952.1
NP_001287201.1
NP_476956.3
NP_996159.1
NP_996160.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6646889..6656048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260023.1 → NP_001246952.1  TBP-associated factor 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246952.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K602, Q29R44
    Conserved Domains (4) summary
    cd05511
    Location:1518 → 1629
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:15 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:652 → 1114
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1388 → 1418
    zf-CCHC_6; Zinc knuckle

  2. NM_206438.2 → NP_996160.1  TBP-associated factor 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996160.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97068, P51123, Q7KSX6, Q7KSX7, Q86LF7, Q9TX96
    UniProtKB/TrEMBL
    Q29R44
    Conserved Domains (4) summary
    cd05511
    Location:1475 → 1586
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:15 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:609 → 1071
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1345 → 1375
    zf-CCHC_6; Zinc knuckle

  3. NM_206437.2 → NP_996159.1  TBP-associated factor 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R44
    Conserved Domains (4) summary
    cd05511
    Location:1475 → 1586
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:15 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:609 → 1071
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1345 → 1375
    zf-CCHC_6; Zinc knuckle

  4. NM_001300272.1 → NP_001287201.1  TBP-associated factor 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LGU9, Q29R44
    Conserved Domains (5) summary
    cd05511
    Location:1475 → 1586
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    PHA03307
    Location:79 → 313
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam09247
    Location:8 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:609 → 1072
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1345 → 1375
    zf-CCHC_6; Zinc knuckle

  5. NM_001170061.1 → NP_001163532.1  TBP-associated factor 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163532.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ72, Q29R44
    Conserved Domains (4) summary
    cd05511
    Location:1475 → 1586
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:15 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:609 → 1071
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1345 → 1375
    zf-CCHC_6; Zinc knuckle

  6. NM_057608.5 → NP_476956.3  TBP-associated factor 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476956.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R44
    Related
    FBpp0081184
    Conserved Domains (4) summary
    cd05511
    Location:1475 → 1586
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:15 → 76
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:609 → 1071
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1345 → 1375
    zf-CCHC_6; Zinc knuckle
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K602 A0A0B4K602
A0A0B4LGU9 A0A0B4LGU9
E1JJ72 E1JJ72
P51123.3 P51123

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