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agt O-6-alkylguanine-DNA alkyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40816, updated on 9-Dec-2024

Summary

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Official Symbol
agtprovided by FlyBase
Official Full Name
O-6-alkylguanine-DNA alkyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0024912
Locus tag
Dmel_CG1303
See related
AllianceGenome:FB:FBgn0024912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Agt; BG:DS00004.10; CG1303; DmAGT; Dmel\CG1303
Summary
Enables methylated-DNA-[protein]-cysteine S-methyltransferase activity. Involved in DNA alkylation repair. Is expressed in organism and wing disc. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See agt in Genome Data Viewer
Location:
84A1-84A1; 3-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6658806..6660100, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2485130..2485822, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Argininosuccinate synthase Neighboring gene TBP-associated factor 1 Neighboring gene uncharacterized protein Neighboring gene twisted bristles roughened eye Neighboring gene labial Neighboring gene Ecdysone-dependent gene 84A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. Kooistra R, et al. Nucleic Acids Res, 1999 Apr 15. PMID 10101186, Free PMC Article
  2. Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids. Liénard MA, et al. Proc Natl Acad Sci U S A, 2016 Jul 19. PMID 27357670, Free PMC Article
  3. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". Araripe LO, et al. BMC Evol Biol, 2010 Dec 14. PMID 21144061, Free PMC Article
  4. Gene Expression as a Dosimeter in Irradiated Drosophila melanogaster. Shrestha S, et al. J Comput Biol, 2017 Dec. PMID 29035581, Free PMC Article
  5. dTcf/Pangolin suppresses growth and tumor formation in Drosophila. Song S, et al. Proc Natl Acad Sci U S A, 2019 Jul 9. PMID 31235567, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA alkylation repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O-6-alkylguanine-DNA alkyltransferase
Names
CG1303-PA
CG1303-PB
agt-PA
agt-PB
NP_001303422.1
NP_477366.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6658806..6660100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316493.1 → NP_001303422.1  O-6-alkylguanine-DNA alkyltransferase, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76339
    Conserved Domains (2) summary
    COG0350
    Location:22 → 190
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    cl29527
    Location:111 → 189
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...

  2. NM_058018.3 → NP_477366.1  O-6-alkylguanine-DNA alkyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477366.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O76339
    Related
    FBpp0081195
    Conserved Domains (2) summary
    COG0350
    Location:22 → 190
    AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
    cl29527
    Location:111 → 189
    ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76339 O76339

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