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pb proboscipedia [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40826, updated on 9-Dec-2024

Summary

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Official Symbol
pbprovided by FlyBase
Official Full Name
proboscipediaprovided by FlyBase
Primary source
FLYBASE:FBgn0051481
Locus tag
Dmel_CG31481
See related
AllianceGenome:FB:FBgn0051481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BG:DS01719.1; CG17880; CG31481; Dmel\CG31481; Dmpb; l(3)04498; Pb; PB; pd; pr
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in proboscis development; specification of segmental identity, labial segment; and specification of segmental identity, maxillary segment. Located in nucleus. Is expressed in several structures, including anterior ectoderm; embryonic segment; embryonic/larval foregut; ganglia; and labial disc. Orthologous to human HOXA2 (homeobox A2) and HOXB2 (homeobox B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
84A5-84A5; 3-48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6707800..6742063, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2533522..2567785, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ccp84Ab Neighboring gene Ccp84Aa Neighboring gene zerknullt-related Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mutant "proboscipedia" in Drosophila melanogaster - A case of hereditary homoösis. Bridges CB, et al. Wilhelm Roux Arch Entwickl Mech Org, 1933 Dec. PMID 28354344
  2. Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila. Benassayag C, et al. Genetics, 1997 Jul. PMID 9215898, Free PMC Article
  3. A homeodomain point mutation of the Drosophila proboscipedia protein provokes eye loss independently of homeotic function. Benassayag C, et al. Mech Dev, 1997 May. PMID 9203141
  4. Analysis of Drosophila proboscipedia mutant alleles. Tayyab I, et al. Genome, 2004 Jun. PMID 15190377
  5. The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis. Pultz MA, et al. Genes Dev, 1988 Jul. PMID 2850265

See all (233) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We also found that a base-mismatch can enable Loqs-PB to tune miRNA length. We speculate that Loqs-PB tunes miRNA length by changing the conformation of base-mismatched nucleotides in the pre-miRNA stem to that of base-matched ones.
    Title: Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem.
  2. Study shows that the LASCY, DYTQL, NANGE motifs, and the C-terminal domain of SCR mediate suppression of induction of ectopic proboscis identity, which would explain why co-expression of PB and SCR is unable to induce ectopic proboscises.
    Title: Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster.
  3. The direct functional antagonism between PB and EY (eyeless) proteins suggests a novel crosstalk mechanism integrating known selector functions in head morphogenesis.
    Title: Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development.
  4. phenotypic analysis of the pb nonsense or frameshift alleles suggests that the C-terminus is an important region required for maxillary palp and proboscis development
    Title: Analysis of Drosophila proboscipedia mutant alleles.
  5. Functions in primary steps of tissue patterning, and leads us to suggest the notion of a homeotic organizer.
    Title: Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: c6739283-6737554 mobile_element_type = transposon:Doc{}1240

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proboscis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in specification of segmental identity, labial segment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in specification of segmental identity, maxillary segment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proboscipedia
Names
CG31481-PA
CG31481-PB
CG31481-PC
CG31481-PD
pb-PA
pb-PB
pb-PC
pb-PD
proboscopedia
proposcipedia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6707800..6742063 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206439.2 → NP_996161.1  proboscipedia, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31264
    Conserved Domains (1) summary
    pfam00046
    Location:192 → 244
    Homeobox; Homeobox domain

  2. NM_206440.2 → NP_996162.1  proboscipedia, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996162.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31264
    Conserved Domains (1) summary
    pfam00046
    Location:197 → 249
    Homeobox; Homeobox domain

  3. NM_206441.2 → NP_996163.1  proboscipedia, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996163.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31264
    Conserved Domains (1) summary
    pfam00046
    Location:197 → 249
    Homeobox; Homeobox domain

  4. NM_057321.5 → NP_476669.3  proboscipedia, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476669.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O97058, P31264, Q4JFI5, Q9VI44
    Related
    FBpp0088333
    Conserved Domains (1) summary
    pfam00046
    Location:202 → 255
    Homeobox; Homeobox domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P31264.2 P31264

Gene LinkOut

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