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Ama Amalgam [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40831, updated on 9-Dec-2024

Summary

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Official Symbol
Amaprovided by FlyBase
Official Full Name
Amalgamprovided by FlyBase
Primary source
FLYBASE:FBgn0000071
Locus tag
Dmel_CG2198
See related
AllianceGenome:FB:FBgn0000071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ama; AMA; BG:DS00276.6; CG2198; CT7244; Dmel\CG2198; M109
Summary
Enables receptor ligand activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of epidermal growth factor receptor signaling pathway; and positive regulation of glial cell proliferation. Located in extracellular space and plasma membrane. Is expressed in several structures, including anlage in statu nascendi; fat body; head epidermis primordium; mesoderm; and sense organ. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NEGR1 (neuronal growth regulator 1); and NTM (neurotrimin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Ama in Genome Data Viewer
Location:
84A5-84A5; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6762593..6765261)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2588315..2590983)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene zerknullt Neighboring gene bicoid Neighboring gene long non-coding RNA:CR45593 Neighboring gene long non-coding RNA:CR44930 Neighboring gene long non-coding RNA::CR42721 Neighboring gene mir-993 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon. Moucaud B, et al. PLoS Biol, 2024 Oct. PMID 39374263, Free PMC Article
  2. The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties. Zeev-Ben-Mordehai T, et al. Biophys J, 2009 Oct 21. PMID 19843464, Free PMC Article
  3. Immunology. Insects diversify one molecule to serve two systems. Du Pasquier L. Science, 2005 Sep 16. PMID 16166509
  4. Amalgam, an axon guidance Drosophila adhesion protein belonging to the immunoglobulin superfamily: over-expression, purification and biophysical characterization. Zeev-Ben-Mordehai T, et al. Protein Expr Purif, 2009 Feb. PMID 18938249
  5. Lachesin: an immunoglobulin superfamily protein whose expression correlates with neurogenesis in grasshopper embryos. Karlstrom RO, et al. Development, 1993 Jun. PMID 8223276

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon.
    Title: Amalgam plays a dual role in controlling the number of leg muscle progenitors and regulating their interactions with the developing Drosophila tendon.
  2. Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain.
    Title: Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain.
  3. In conjunction with its receptor Neurotactin (Nrt) and the effector kinase Abelson tyrosine kinase (Abl), Ama is necessary in parallel to the cell-autonomous Dfd pathway for the correct specification of the maxillary identity of NB6-4
    Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
  4. In this study we performed a comprehensive biophysical characterization of the multidomain Drosophila adhesion glycoprotein Ama, and determined its 3D structure in solution to 20 A resolution
    Title: The quaternary structure of amalgam, a Drosophila neuronal adhesion protein, explains its dual adhesion properties.
  5. amalgam, neurotactin and the Abelson tyrosine kinase interact and affect axon pathfinding
    Title: Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in maintenance of blood-brain barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of glial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
amalgam
Names
Ama-PA
Ama-PB
Ama-PC
CG2198-PA
CG2198-PB
CG2198-PC
amalgam shotgun

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    6762593..6765261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169160.1 → NP_731114.2  amalgam, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731114.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSX2
    Related
    FBpp0081135, FBtr0081618
    Conserved Domains (4) summary
    smart00408
    Location:161 → 223
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:154 → 234
    IG_like; Immunoglobulin like
    pfam07679
    Location:33 → 143
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:37 → 127
    Ig; Immunoglobulin domain

  2. NM_057231.4 → NP_476579.1  amalgam, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476579.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15364, Q9V3A5
    UniProtKB/TrEMBL
    A4V2I0
    Related
    FBpp0081136
    Conserved Domains (4) summary
    smart00408
    Location:153 → 215
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:146 → 226
    IG_like; Immunoglobulin like
    pfam07679
    Location:25 → 135
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:29 → 119
    Ig; Immunoglobulin domain

  3. NM_176412.2 → NP_788589.1  amalgam, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788589.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15364, Q9V3A5
    UniProtKB/TrEMBL
    A4V2I0
    Related
    FBpp0081137
    Conserved Domains (4) summary
    smart00408
    Location:153 → 215
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:146 → 226
    IG_like; Immunoglobulin like
    pfam07679
    Location:25 → 135
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:29 → 119
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V2I0 A4V2I0
P15364.2 P15364
Q7KSX2 Q7KSX2

Gene LinkOut

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