Tailor tailor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tailorprovided by FlyBase
Official Full Name: tailorprovided by FlyBase
Primary source: FLYBASE:FBgn0037470
Locus tag: Dmel_CG1091
See related: AllianceGenome:FB:FBgn0037470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.222; CG1091; Dmel\CG1091; DmTailor; TAIL; tailor; TUTase6
Summary: Enables RNA uridylyltransferase activity. Involved in RNA 3' uridylation; positive regulation of miRNA catabolic process; and pre-miRNA processing. Located in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; gut section; and somatic trunk mesoderm derivative. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 84B2-84B2; 3-48 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7083225..7086083, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (2908947..2911805, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our work reveals useful insights to explain why Drosophila Tailor can preferentially select RNA substrates ending in 3'G and provides important values for further understanding the biological significances of biogenesis pathway of mirtron in flies.
Title: Structural insights into a unique preference for 3' terminal guanine of mirtron in Drosophila TUTase tailor.
Analysis of crystal structures reveal specific amino acid residues of Tailor that are involved in donor and acceptor substrate recognition, and complementary biochemical assays confirm the critical role of an active site arginine in conferring selectivity toward 3'-guanosine terminated RNAs.
Title: Structural basis for acceptor RNA substrate selectivity of the 3' terminal uridylyl transferase Tailor.
The mutants of Tailor and Dis3L2 are viable and lack overt morphological defects. Instead, these mutants exhibit defects in female and male fertility, implying specific requirements in the germline.
Title: Characterization of a TUTase/RNase complex required for Drosophila gametogenesis.
Tailor is an uridylyltransferase that is required for the majority of 3' end modifications of microRNAs and predominantly targets precursor hairpins
Title: Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila.
detect preferential activity of Tailor on 3'-G canonical pre-miRNAs, and specific depletion of such loci from the pool of conserved miRNAs
Title: Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

kalpha1 (e-PCR)
- UniSTS:205590

D1S3688 (e-PCR)
- UniSTS:474266

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA uridylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA 3' uridylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA 3' uridylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of miRNA catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tailor

Names: 3' terminal uridylyl transferase 6; CG1091-PA; CG1091-PB; CG1091-PC; TUTase; Tailor-PA; Tailor-PB; Tailor-PC

NP_001262327.1

EC 2.7.7.52

NP_649693.3

EC 2.7.7.52

NP_731129.1

EC 2.7.7.52

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

7083225..7086083 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141436.3 → NP_649693.3 tailor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649693.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VI58

Related

FBpp0081154

Conserved Domains (2) summary

cd05402
Location:245 → 361

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

cl06345
Location:70 → 126

DUF1439; Protein of unknown function (DUF1439)
NM_001275398.1 → NP_001262327.1 tailor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262327.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGN4

Conserved Domains (2) summary

cd05402
Location:245 → 364

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

cl06345
Location:70 → 126

DUF1439; Protein of unknown function (DUF1439)
NM_169169.3 → NP_731129.1 tailor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731129.1

Status: REVIEWED

UniProtKB/TrEMBL

Q86BP3

Related

FBpp0081155

Conserved Domains (3) summary

cd05402
Location:190 → 306

NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases

pfam09249
Location:456 → 496

tRNA_NucTransf2; tRNA nucleotidyltransferase, second domain

cl06345
Location:15 → 71

DUF1439; Protein of unknown function (DUF1439)