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CG10068 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40852, updated on 9-Dec-2024

Summary

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Official Symbol
CG10068provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037473
Locus tag
Dmel_CG10068
See related
AllianceGenome:FB:FBgn0037473
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10068
Summary
Predicted to enable GTPase activator activity. Involved in axoneme assembly and ciliary transition zone assembly. Located in ciliary basal body. Is expressed in adult head and organism. Orthologous to several human genes including ELMOD2 (ELMO domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG10068 in Genome Data Viewer
Location:
84C4-84C4; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7126271..7128027, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2951993..2953749, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Alhambra Neighboring gene long non-coding RNA:CR45906 Neighboring gene Muscle LIM protein at 84B Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Glycine-TCC 1-1 Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila muscle LIM protein, Mlp84B, cooperates with D-titin to maintain muscle structural integrity. Clark KA, et al. J Cell Sci, 2007 Jun 15. PMID 17535853
  2. A phylogenetic profiling approach identifies novel ciliogenesis genes in Drosophila and C. elegans. Dobbelaere J, et al. EMBO J, 2023 Aug 15. PMID 37317646, Free PMC Article
  3. Terminal cytokinesis events uncovered after an RNAi screen. Echard A, et al. Curr Biol, 2004 Sep 21. PMID 15380073, Free PMC Article
  4. Novel regulators of planar cell polarity: a genetic analysis in Drosophila. Weber U, et al. Genetics, 2012 May. PMID 22391484, Free PMC Article
  5. Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing. Sutton DC, et al. PLoS One, 2024. PMID 38412189, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ciliary transition zone assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG10068-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7126271..7128027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141438.4 → NP_649695.1  uncharacterized protein Dmel_CG10068 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649695.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VI65
    Related
    FBpp0081128
    Conserved Domains (1) summary
    pfam04727
    Location:126 → 284
    ELMO_CED12; ELMO/CED-12 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VI65 Q9VI65

Gene LinkOut

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