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MAGE MAGE [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40860, updated on 4-Jan-2025

Summary

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Official Symbol
MAGEprovided by FlyBase
Official Full Name
MAGEprovided by FlyBase
Primary source
FLYBASE:FBgn0037481
Locus tag
Dmel_CG10059
See related
AllianceGenome:FB:FBgn0037481
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10059; DMAGE; Dmel\CG10059; Mage; Nse3; sst
Summary
Involved in DNA damage response; negative regulation of neuroblast proliferation; and negative regulation of neuron apoptotic process. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Is expressed in several structures, including antennal primordium; central brain primordium; ganglia; head epidermis primordium; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in Bartter disease type 5; Prader-Willi syndrome; and Schaaf-Yang syndrome. Orthologous to several human genes including MAGEA8 (MAGE family member A8); MAGEB16 (MAGE family member B16); and MAGEB2 (MAGE family member B2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See MAGE in Genome Data Viewer
Location:
84C7-84C7; 3-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7154238..7155180, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2979960..2980902, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene GST-containing FLYWCH zinc-finger protein Neighboring gene Spindle assembly abnormal 4 Neighboring gene antisense RNA:CR45909 Neighboring gene stranded at second Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the first invertebrate MAGE paralogue: an epitope that activates T-cells in humans is highly conserved in evolution. Põld M, et al. Dev Comp Immunol, 2000 Dec. PMID 10906385
  2. Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis. Shimaji K, et al. Genes Cells, 2015 Nov. PMID 26334932
  3. Expression of Drosophila MAGE gene encoding a necdin homologous protein in postembryonic neurogenesis. Nishimura I, et al. Gene Expr Patterns, 2007 Jan. PMID 17084677
  4. Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis. Nishimura I, et al. Neuroscience, 2008 Jun 23. PMID 18479827
  5. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. Li X, et al. PLoS One, 2013. PMID 23555814, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAGE is involved in both neural stem cell proliferation and neuronal survival during nervous system development
    Title: Drosophila MAGE controls neural precursor proliferation in postembryonic neurogenesis.
  2. These results indicate that MAGE expression lasts throughout the postembryonic neurogenesis in Drosophila.
    Title: Expression of Drosophila MAGE gene encoding a necdin homologous protein in postembryonic neurogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Smc5-Smc6 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MAGE
Names
CG10059-PA
MAGE-PA
necdin
sleepless in seattle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7154238..7155180 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141445.3 → NP_649702.2  MAGE [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649702.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9I7L4, Q9ND98
    Related
    FBpp0081124
    Conserved Domains (1) summary
    pfam01454
    Location:36 → 201
    MAGE; MAGE family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9I7L4 Q9I7L4
Q9ND98 Q9ND98

Gene LinkOut

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