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alpha-Est8 alpha-Esterase-8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40899, updated on 9-Dec-2024

Summary

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Official Symbol
alpha-Est8provided by FlyBase
Official Full Name
alpha-Esterase-8provided by FlyBase
Primary source
FLYBASE:FBgn0015576
Locus tag
Dmel_CG1121
See related
AllianceGenome:FB:FBgn0015576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aE8; alphaE8; CG1121; DmalphaE8; Dmel\CG1121; Est8; I
Summary
Predicted to enable carboxylesterase activity. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See alpha-Est8 in Genome Data Viewer
Location:
84D9-84D9; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7509343..7515670, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3335065..3341392, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-10 Neighboring gene alpha-Esterase-9 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial morphology and cristae structure 1 Neighboring gene alpha-Esterase-7 Neighboring gene Ubiquitin conjugating enzyme 84D

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
  2. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
  3. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090
  4. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
  5. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  

General protein information

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Preferred Names
alpha-Esterase-8
Names
CG1121-PA
alpha-Est8-PA
fragment I
NP_524259.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7509343..7515670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079535.3 → NP_524259.2  alpha-Esterase-8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524259.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRB9, Q9VIB3
    Related
    FBpp0081077
    Conserved Domains (2) summary
    COG0657
    Location:116 → 221
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:29 → 564
    COesterase; Carboxylesterase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24202 Q24202
Q8MRB9 Q8MRB9
Q9VIB3 Q9VIB3

Gene LinkOut

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