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Rtnl2 Rtnl2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40903, updated on 9-Dec-2024

Summary

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Official Symbol
Rtnl2provided by FlyBase
Official Full Name
Rtnl2provided by FlyBase
Primary source
FLYBASE:FBgn0015831
Locus tag
Dmel_CG1279
See related
AllianceGenome:FB:FBgn0015831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.134; CG1279; Dmel\CG1279; rtnl2; Tml84D; trop
Summary
Enables phospholipid binding activity. Involved in endoplasmic reticulum tubular network organization and membrane bending. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Rtnl2 in Genome Data Viewer
Location:
84D9-84D9; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7528864..7530241, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3354586..3355963, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Esterase-7 Neighboring gene alpha-Esterase-6 Neighboring gene pseudo Neighboring gene alpha-Tubulin at 84D Neighboring gene alpha-Esterase-5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon. Espadas J, et al. Nat Commun, 2019 Nov 22. PMID 31757972, Free PMC Article
  2. Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics. Pérez-Moreno JJ, et al. J Cell Biol, 2023 Jun 5. PMID 36952540, Free PMC Article
  3. Development of dendrite polarity in Drosophila neurons. Hill SE, et al. Neural Dev, 2012 Oct 30. PMID 23111238, Free PMC Article
  4. Molecular cloning of an alpha-esterase gene cluster on chromosome 3r of Drosophila melanogaster. Russell RJ, et al. Insect Biochem Mol Biol, 1996 Mar. PMID 8900595
  5. Kinesin-2 and Apc function at dendrite branch points to resolve microtubule collisions. Weiner AT, et al. Cytoskeleton (Hoboken), 2016 Jan. PMID 26785384, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane bending IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rtnl2
Names
CG1279-PB
CG1279-PC
Reticulon-2
Rtnl2-PB
Rtnl2-PC
Tropomyosin-like-84D
tropomyosin-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7528864..7530241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260035.1 → NP_001246964.1  Rtnl2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246964.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C3KGL7, Q9VIB7
    Conserved Domains (1) summary
    pfam02453
    Location:21 → 183
    Reticulon; Reticulon

  2. NM_079539.2 → NP_524263.2  Rtnl2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524263.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C3KGL7, Q9VIB7
    Conserved Domains (1) summary
    pfam02453
    Location:21 → 183
    Reticulon; Reticulon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24199 Q24199
Q9VIB7 Q9VIB7

Gene LinkOut

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