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alpha-Est4 alpha-Esterase-4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40906, updated on 4-Jan-2025

Summary

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Official Symbol
alpha-Est4provided by FlyBase
Official Full Name
alpha-Esterase-4provided by FlyBase
Primary source
FLYBASE:FBgn0015572
Locus tag
Dmel_CG1082
See related
AllianceGenome:FB:FBgn0015572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
aE4; alphaE4; C; CG1082; DmalphaE4; Dmel\CG1082; FBgn0015572
Summary
Predicted to enable carboxylesterase activity. Is expressed in adult head; embryonic midgut chamber; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See alpha-Est4 in Genome Data Viewer
Location:
84D9-84D9; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7536687..7538615, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3362409..3364337, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 84D Neighboring gene alpha-Esterase-5 Neighboring gene antisense RNA:CR46128 Neighboring gene alpha-Esterase-3 Neighboring gene alpha-Esterase-2 Neighboring gene antisense RNA:CR46129

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carboxyl/cholinesterases: a case study of the evolution of a successful multigene family. Oakeshott JG, et al. Bioessays, 1999 Dec. PMID 10580988
  2. Developmental expression and gene/enzyme identifications in the alpha esterase gene cluster of Drosophila melanogaster. Campbell PM, et al. Insect Mol Biol, 2003 Oct. PMID 12974951
  3. Duplication and divergence of the genes of the alpha-esterase cluster of Drosophila melanogaster. Robin C, et al. J Mol Evol, 1996 Sep. PMID 8703090
  4. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
  5. Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7. Birner-Gruenberger R, et al. Insect Biochem Mol Biol, 2012 Mar. PMID 22198472

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carboxylesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
alpha-Esterase-4
Names
CG1082-PA
alpha-Est4-PA
fragment C
NP_524266.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7536687..7538615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079542.4 → NP_524266.1  alpha-Esterase-4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524266.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24197, Q9VIC0
    Related
    FBpp0081070
    Conserved Domains (2) summary
    COG0657
    Location:104 → 219
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cl21494
    Location:7 → 529
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24197 Q24197
Q9VIC0 Q9VIC0

Gene LinkOut

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