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sgll sugarlethal [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40925, updated on 4-Jan-2025

Summary

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Official Symbol
sgllprovided by FlyBase
Official Full Name
sugarlethalprovided by FlyBase
Primary source
FLYBASE:FBgn0051472
Locus tag
Dmel_CG31472
See related
AllianceGenome:FB:FBgn0051472
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2649; CG31472; Dmel\CG31472; dPNPO; Sgll
Summary
Enables pyridoxamine phosphate oxidase activity. Involved in pyridoxal phosphate biosynthetic process and response to sucrose. Predicted to be located in mitochondrial intermembrane space. Is expressed in adult head and organism. Used to study pyridoxamine 5'-phosphate oxidase deficiency. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See sgll in Genome Data Viewer
Location:
84E1-84E1; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7810532..7811912)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3636254..3637634)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46127

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila carrying epilepsy-associated variants in the vitamin B6 metabolism gene PNPO display allele- and diet-dependent phenotypes. Chi W, et al. Proc Natl Acad Sci U S A, 2022 Mar 1. PMID 35217610, Free PMC Article
  2. The multifaceted role of vitamin B(6) in cancer: Drosophila as a model system to investigate DNA damage. Contestabile R, et al. Open Biol, 2020 Mar. PMID 32208818, Free PMC Article
  3. Pyridox (am) ine 5'-phosphate oxidase deficiency induces seizures in Drosophila melanogaster. Chi W, et al. Hum Mol Genet, 2019 Sep 15. PMID 31261385, Free PMC Article
  4. A nutritional conditional lethal mutant due to pyridoxine 5'-phosphate oxidase deficiency in Drosophila melanogaster. Chi W, et al. G3 (Bethesda), 2014 Apr 16. PMID 24739647, Free PMC Article
  5. Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila. Mascolo E, et al. J Cell Physiol, 2020 Jan. PMID 31506944

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila.
    Title: Pyridoxine/pyridoxamine 5'-phosphate oxidase (Sgll/PNPO) is important for DNA integrity and glucose homeostasis maintenance in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxamine phosphate oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxamine phosphate oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxamine phosphate oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in pyridoxal phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridoxal phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyridoxine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to sucrose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vitamin B6 metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sugarlethal
Names
CG31472-PA
CG31472-PB
pyridoxine 5'-phosphate oxidase
sgll-PA
sgll-PB
NP_731186.2
NP_731187.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7810532..7811912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169195.4 → NP_731187.1  sugarlethal, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731187.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSW3
    Related
    FBpp0081245
    Conserved Domains (3) summary
    TIGR00558
    Location:33 → 237
    pdxH; pyridoxamine-phosphate oxidase
    pfam01243
    Location:50 → 126
    Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
    pfam10590
    Location:182 → 237
    PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region

  2. NM_169194.4 → NP_731186.2  sugarlethal, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731186.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MS89, Q9VHZ5
    Related
    FBpp0081244
    Conserved Domains (3) summary
    TIGR00558
    Location:42 → 246
    pdxH; pyridoxamine-phosphate oxidase
    pfam01243
    Location:59 → 135
    Pyridox_oxidase; Pyridoxamine 5'-phosphate oxidase
    pfam10590
    Location:191 → 246
    PNPOx_C; Pyridoxine 5'-phosphate oxidase C-terminal dimerization region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KSW3 Q7KSW3
Q9VHZ5 Q9VHZ5

Gene LinkOut

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