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kipf kipferl [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40937, updated on 9-Dec-2024

Summary

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Official Symbol
kipfprovided by FlyBase
Official Full Name
kipferlprovided by FlyBase
Primary source
FLYBASE:FBgn0014931
Locus tag
Dmel_CG2678
See related
AllianceGenome:FB:FBgn0014931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-84Eb; B; CG2678; Dmel\CG2678; Kipf
Summary
Enables chromatin DNA binding activity; chromatin-protein adaptor activity; and sequence-specific double-stranded DNA binding activity. Involved in positive regulation of piRNA transcription. Located in cytosol. Is expressed in adult brain cell body rind and organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See kipf in Genome Data Viewer
Location:
84E5-84E5; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7913851..7916550)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3739573..3742272)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene TBP-associated factor 7 Neighboring gene Phosphoribosylamidotransferase Neighboring gene Riboflavin kinase Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU2-C41 Neighboring gene lodestar

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic control of a sex-specific piRNA program. Chen P, et al. Curr Biol, 2023 May 8. PMID 37059098, Free PMC Article
  2. Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals. Baumgartner L, et al. Elife, 2024 Jul 12. PMID 38995818, Free PMC Article
  3. Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein. Girdham CH, et al. Genes Dev, 1991 Oct. PMID 1916263
  4. A molecular analysis of doublesex, a bifunctional gene that controls both male and female sexual differentiation in Drosophila melanogaster. Baker BS, et al. Genes Dev, 1988 Apr. PMID 2453394
  5. Molecular and genetic analyses of Drosophila Prat, which encodes the first enzyme of de novo purine biosynthesis. Clark DV. Genetics, 1994 Feb. PMID 8150282, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 7915828-7915889 mobile_element_type = transposon:INE-1{}1840

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin-protein adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of piRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
kipferl
Names
CG2678-PA
CG2678-PB
kipf-PA
kipf-PB
transcript B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    7913851..7916550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260044.2 → NP_001246973.1  kipferl, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246973.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D4G7A6
    Conserved Domains (4) summary
    smart00868
    Location:8 → 85
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5048
    Location:220 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:249 → 271
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_141493.4 → NP_649750.1  kipferl, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649750.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D4G7A6, D4G7A7, O76205, Q8T053, Q9VHY3
    Related
    FBpp0081254
    Conserved Domains (4) summary
    smart00868
    Location:8 → 85
    zf-AD; Zinc-finger associated domain (zf-AD)
    COG5048
    Location:220 → 284
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:223 → 243
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:249 → 271
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4G7A6 D4G7A6
Q8T053.1 Q8T053

Gene LinkOut

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