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CG10435 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40948, updated on 4-Jan-2025

Summary

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Official Symbol
CG10435provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037539
Locus tag
Dmel_CG10435
See related
AllianceGenome:FB:FBgn0037539
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10435
Summary
Predicted to enable ubiquitin binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be part of ESCRT I complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 80. Orthologous to several human genes including UBAP1 (ubiquitin associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG10435 in Genome Data Viewer
Location:
84E8-84E8; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8010907..8013201, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3836629..3838923, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 95kD Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A functional genomic screen for cardiogenic genes using RNA interference in developing Drosophila embryos. Kim YO, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14684833, Free PMC Article
  2. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article
  3. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10435-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8010907..8013201 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141502.3 → NP_649759.1  uncharacterized protein Dmel_CG10435 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649759.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHX1
    Related
    FBpp0081310
    Conserved Domains (1) summary
    cd14316
    Location:458 → 494
    UBA2_UBAP1_like; UBA2 domain found in ubiquitin-associated protein 1 (UBAP-1) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHX1 Q9VHX1

Gene LinkOut

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