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Pbp95 PSEA-binding protein 95kD [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40949, updated on 4-Jan-2025

Summary

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Official Symbol
Pbp95provided by FlyBase
Official Full Name
PSEA-binding protein 95kDprovided by FlyBase
Primary source
FLYBASE:FBgn0037540
Locus tag
Dmel_CG2702
See related
AllianceGenome:FB:FBgn0037540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.359; BEST:LD28511; CG2702; Dmel\CG2702; DmPBP; DmPBP95; DmSNAP190; DmSNAPc
Summary
Enables RNA polymerase III type 3 promoter sequence-specific DNA binding activity and bent DNA binding activity. Contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in protein-DNA complex assembly; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Part of snRNA-activating protein complex. Is expressed in organism. Orthologous to human SNAPC4 (small nuclear RNA activating complex polypeptide 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Pbp95 in Genome Data Viewer
Location:
84E8-84E8; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8013791..8016610)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3839513..3842332)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a Drosophila proximal-sequence-element-binding protein involved in transcription of small nuclear RNA genes. Su Y, et al. Eur J Biochem, 1997 Aug 15. PMID 9310383
  2. Similarities and differences in the conformation of protein-DNA complexes at the U1 and U6 snRNA gene promoters. Hardin SB, et al. Nucleic Acids Res, 2000 Jul 15. PMID 10908334, Free PMC Article
  3. A map of Drosophila melanogaster small nuclear RNA-activating protein complex (DmSNAPc) domains involved in subunit assembly and DNA binding. Hung KH, et al. J Biol Chem, 2009 Aug 21. PMID 19556241, Free PMC Article
  4. Regulation of snRNA gene expression by the Drosophila melanogaster small nuclear RNA activating protein complex (DmSNAPc). Hung KH, et al. Crit Rev Biochem Mol Biol, 2011 Feb. PMID 20925482
  5. Localization of residues in a novel DNA-binding domain of DmSNAP43 required for DmSNAPc DNA-binding activity. Hung KH, et al. FEBS Lett, 2012 Mar 23. PMID 22449969

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results of the study are consistent with a model in which the specific DNA sequences of the U1 and U6 Promoter differentially alter the conformation of DmSNAPc, leading to the subsequent recruitment of different RNA polymerases to the U1 and U6 gene promoters.
    Title: The Myb domain of the largest subunit of SNAPc adopts different architectural configurations on U1 and U6 snRNA gene promoter sequences.
  2. The results reveal the topological arrangement of the 4.5 SNAP190 Myb repeats relative to the DNA and to each other when SNAP190 is bound to a U1 promoter as a subunit of SNAPc.
    Title: Architectural arrangement of the small nuclear RNA (snRNA)-activating protein complex 190 subunit (SNAP190) on U1 snRNA gene promoter DNA.
  3. The results indicated that the C-terminal domain of DmSNAP190 is essential for DmSNAPc to bind efficiently to the PSEA, even though it is not required for assembly with either DmSNAP43 or DmSNAP50 .
    Title: A map of Drosophila melanogaster small nuclear RNA-activating protein complex (DmSNAPc) domains involved in subunit assembly and DNA binding.
  4. Results support a model in which conformational differences in proximal sequence element binding protein (DmPBP)-DNA complexes lead to selective RNA polymerase recruitment to U1 and U6 promoters.
    Title: Architectural arrangement of cloned proximal sequence element-binding protein subunits on Drosophila U1 and U6 snRNA gene promoters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables bent DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein-DNA complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
involved_in snRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of snRNA-activating protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of snRNA-activating protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of snRNA-activating protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
PSEA-binding protein 95kD
Names
CG2702-PA
PSEA-binding protein
Pbp95-PA
drosophila melanogaster PSE-binding protein 95-kDa subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8013791..8016610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141503.4 → NP_649760.1  PSEA-binding protein 95kD [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649760.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHX0
    Related
    FBpp0081282
    Conserved Domains (5) summary
    smart00717
    Location:229 → 276
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:229 → 275
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam13921
    Location:287 → 350
    Myb_DNA-bind_6; Myb-like DNA-binding domain
    cl01888
    Location:4 → 74
    DUF883; Bacterial protein of unknown function (DUF883)
    cl21498
    Location:194 → 240
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHX0 Q9VHX0

Gene LinkOut

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