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nac neuronally altered carbohydrate [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40981, updated on 4-Jan-2025

Summary

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Official Symbol
nacprovided by FlyBase
Official Full Name
neuronally altered carbohydrateprovided by FlyBase
Primary source
FLYBASE:FBgn0265351
Locus tag
Dmel_CG9620
See related
AllianceGenome:FB:FBgn0265351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9620; Dmel\CG9620; gfr; Gfr; Nac
Summary
Enables GDP-fucose transmembrane transporter activity. Involved in GDP-fucose import into Golgi lumen; N-glycan fucosylation; and protein O-linked fucosylation. Located in Golgi membrane and Golgi-associated vesicle. Is expressed in adult head. Used to study congenital disorder of glycosylation type II. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Orthologous to human SLC35C1 (solute carrier family 35 member C1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nac in Genome Data Viewer
Location:
84F10-84F10; 3-48 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8302686..8304023, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4128408..4129745, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene suppressor-of-G2-allele-of-skp1 Neighboring gene mir-4918 stem loop Neighboring gene tex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster. Lühn K, et al. Exp Cell Res, 2004 Dec 10. PMID 15530860
  2. The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter. Geisler C, et al. J Biol Chem, 2012 Aug 24. PMID 22745127, Free PMC Article
  3. A carbohydrate epitope expressed uniquely on the cell surface of Drosophila neurons is altered in the mutant nac (neurally altered carbohydrate). Katz F, et al. EMBO J, 1988 Nov. PMID 2463162, Free PMC Article
  4. Neural-specific carbohydrate moiety shared by many surface glycoproteins in Drosophila and grasshopper embryos. Snow PM, et al. J Neurosci, 1987 Dec. PMID 3320283, Free PMC Article
  5. Characterization of nervana, a Drosophila melanogaster neuron-specific glycoprotein antigen recognized by anti-horseradish peroxidase antibodies. Sun B, et al. J Neurochem, 1995 Jul. PMID 7540667

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the nac(1) Gfr mutation produces a previously unrecognized general defect in N-glycan core fucosylation.
    Title: The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter.
  2. Data show that Gfr and Efr function redundantly in the O-fucosylation of Notch, although they had different localizations and nucleotide sugar transportation specificities.
    Title: Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.
  3. study gives experimental proof that the product of the in silico identified Drosophila gene CG9620 serves as a functional GDP-fucose transporter
    Title: Identification and molecular cloning of a functional GDP-fucose transporter in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables CMP-N-acetylneuraminate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-fucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-fucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-fucose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT enables GDP-mannose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables UDP-N-acetylgalactosamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables UDP-N-acetylglucosamine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables UDP-galactose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables UDP-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables UDP-glucuronic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in CMP-N-acetylneuraminate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP-fucose import into Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in GDP-fucose import into Golgi lumen IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GDP-fucose import into Golgi lumen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GDP-fucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in GDP-mannose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-glycan fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in UDP-N-acetylgalactosamine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in UDP-N-acetylglucosamine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in UDP-galactose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in UDP-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in UDP-glucuronic acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked fucosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neuronally altered carbohydrate
Names
CG9620-PA
Gfr
golgi GDP-fucose transporter
nac-PA
neurally altered carbohydrate
neuronally-altered-carbohydrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8302686..8304023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141525.2 → NP_649782.1  neuronally altered carbohydrate [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649782.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53YF6, Q9VHT4
    Related
    FBpp0081352
    Conserved Domains (1) summary
    pfam03151
    Location:16 → 281
    TPT; Triose-phosphate Transporter family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHT4.1 Q9VHT4

Gene LinkOut

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