CG7483 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG7483provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0037573
Locus tag: Dmel_CG7483
See related: AllianceGenome:FB:FBgn0037573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 7483; anon-WO0118547.364; Dmel\CG7483; DmRH28; eIF4A; eIF4A-III; eIF4A3; eIF4AII; eIF4aIII; eIF4AIII; EIF4AIII; elF4AIII; l(3)84Fi
Summary: Predicted to enable RNA helicase activity and mRNA binding activity. Involved in several processes, including RNA splicing; exon-exon junction complex assembly; and pole plasm oskar mRNA localization. Located in nucleus and pole plasm. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8313208..8314864)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4138930..4140586)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA splicing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exon-exon junction complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in pole plasm oskar mRNA localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in pole plasm	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed

Names: CG7483-PA; eIF4AIII; eukaryotic translation initiation factor 4AIII; lethal(3)84Fi

NP_649788.2

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The following sections contain reference sequences that belong to a specific genome build. Explain