Coq2 Coenzyme Q biosynthesis protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Coq2provided by FlyBase
Official Full Name: Coenzyme Q biosynthesis protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0037574
Locus tag: Dmel_CG9613
See related: AllianceGenome:FB:FBgn0037574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9613; coq2; COQ2; Dmel\CG9613; sbo
Summary: Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Involved in defense response to other organism and determination of adult lifespan. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head; embryonic/larval midgut; indirect flight muscle cell; and organism. Used to study nephrotic syndrome and primary coenzyme Q10 deficiency 1. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 84F11-84F11; 3-48 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (8314784..8316543, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (4140506..4142265, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

flies defective in CoQ biosynthetic gene coq2 were more susceptible to bacterial and fungal infections, while were more resistant to viruses
Title: Coenzyme Q plays opposing roles on bacteria/fungi and viruses in Drosophila innate immunity.
sbo is an essential gene for Drosophila development, mutation of which leads to an extension of lifespan most likely by altering endogenous CoQ biosynthesis.
Title: Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 4-hydroxybenzoate polyprenyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables prenyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: coenzyme Q biosynthesis protein 2

Names: CG9613-PA; Coq2-PA; small boy

NP_649789.1

EC 2.5.1.-

EC 2.5.1.39

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

8314784..8316543 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_141532.3 → NP_649789.1 coenzyme Q biosynthesis protein 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649789.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VHS7

Related

FBpp0081347

Conserved Domains (1) summary

cl00337
Location:73 → 358

PT_UbiA; UbiA family of prenyltransferases (PTases)