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hb - hunchback

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuroblast fate determination; regulation of neural precursor cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; glial cell; head epidermis primordium; larval neurons; and somatic precursor cell. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa