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TMEM216 Transmembrane protein 216 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41035, updated on 9-Dec-2024

Summary

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Official Symbol
TMEM216provided by FlyBase
Official Full Name
Transmembrane protein 216provided by FlyBase
Primary source
FLYBASE:FBgn0037614
Locus tag
Dmel_CG8116
See related
AllianceGenome:FB:FBgn0037614
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8116; Dmel\CG8116; EP(3)3246; GH04517
Summary
Predicted to be involved in non-motile cilium assembly. Predicted to be located in cilium. Predicted to be active in ciliary transition zone. Is expressed in organism. Human ortholog(s) of this gene implicated in Joubert syndrome; Joubert syndrome 2; and Meckel syndrome 2. Orthologous to several human genes including TMEM216 (transmembrane protein 216). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See TMEM216 in Genome Data Viewer
Location:
85A8-85A9; 3-48 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8716243..8721320)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4541965..4547042)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene hunchback Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene numerous disordered muscles

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila sensory cilia lacking MKS proteins exhibit striking defects in development but only subtle defects in adults. Pratt MB, et al. J Cell Sci, 2016 Oct 15. PMID 27577095, Free PMC Article
  2. Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen. Azad P, et al. G3 (Bethesda), 2012 Oct. PMID 23050227, Free PMC Article
  3. Functional analysis of the Drosophila embryonic germ cell transcriptome by RNA interference. Jankovics F, et al. PLoS One, 2014. PMID 24896584, Free PMC Article
  4. A misexpression study examining dorsal thorax formation in Drosophila melanogaster. Peña-Rangel MT, et al. Genetics, 2002 Mar. PMID 11901120, Free PMC Article
  5. Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis. Lin WH, et al. Dis Model Mech, 2017 Feb 1. PMID 28067623, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
transmembrane protein 216
Names
CG8116-PA
CG8116-PB
CG8116-PC
TMEM216-PA
TMEM216-PB
TMEM216-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8716243..8721320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170082.2 → NP_001163553.1  transmembrane protein 216, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163553.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHN0
    Conserved Domains (1) summary
    pfam09799
    Location:12 → 115
    Transmemb_17; Predicted membrane protein

  2. NM_141561.4 → NP_649818.1  transmembrane protein 216, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHN0
    Related
    FBpp0081388
    Conserved Domains (1) summary
    pfam09799
    Location:12 → 115
    Transmemb_17; Predicted membrane protein

  3. NM_001170083.2 → NP_001163554.1  transmembrane protein 216, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163554.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHN0
    Conserved Domains (1) summary
    pfam09799
    Location:12 → 115
    Transmemb_17; Predicted membrane protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHN0 Q9VHN0

Gene LinkOut

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