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Iru Iruka [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41080, updated on 4-Jan-2025

Summary

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Official Symbol
Iruprovided by FlyBase
Official Full Name
Irukaprovided by FlyBase
Primary source
FLYBASE:FBgn0037653
Locus tag
Dmel_CG11982
See related
AllianceGenome:FB:FBgn0037653
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11982; Dmel\CG11982
Summary
Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including RNF126 (ring finger protein 126). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Iru in Genome Data Viewer
Location:
85C2-85C2; 3-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9006456..9008030)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4832178..4833752)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta3 subunit Neighboring gene uncharacterized protein Neighboring gene Potassium channel modulatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State. Kobayashi H, et al. Mol Cell, 2019 Jan 3. PMID 30503771
  2. VCP Machinery Mediates Autophagic Degradation of Empty Argonaute. Kobayashi H, et al. Cell Rep, 2019 Jul 30. PMID 31365860
  3. E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein. Weiler KS. Genetics, 2007 Sep. PMID 17660546, Free PMC Article
  4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
  5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
iruka
Names
CG11982-PA
Iru-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9006456..9008030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141602.4 → NP_649859.1  iruka [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VHI7
    Related
    FBpp0081445
    Conserved Domains (3) summary
    COG5243
    Location:253 → 372
    HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
    cd16667
    Location:252 → 294
    RING-H2_RNF126_like; RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
    pfam14369
    Location:16 → 46
    zinc_ribbon_9; zinc-ribbon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VHI7.1 Q9VHI7

Gene LinkOut

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