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pum - pumilio

Enables CCR4-NOT complex binding activity and nucleic acid binding activity. Involved in several processes, including behavioral response to ethanol; head involution; and positive regulation of mRNA catabolic process. Located in neuronal ribonucleoprotein granule and nuclear envelope. Is active in muscle cell postsynaptic specialization; type Ib terminal bouton; and type Is terminal bouton. Is expressed in several structures, including adult brain cell body rind; adult head; border follicle cell; cuboidal/columnar epithelium; and germline cell. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Orthologous to several human genes including PUM2 (pumilio RNA binding family member 2). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa