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Vps15 Vacuolar protein sorting 15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41096, updated on 9-Dec-2024

Summary

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Official Symbol
Vps15provided by FlyBase
Official Full Name
Vacuolar protein sorting 15provided by FlyBase
Primary source
FLYBASE:FBgn0260935
Locus tag
Dmel_CG9746
See related
AllianceGenome:FB:FBgn0260935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9746; Dmel\CG9746; dVps15; FBgn0260935; ird; ird1; Ird1; p150; vps15; VPS15
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including cellular response to amino acid starvation; larval midgut cell programmed cell death; and neuron remodeling. Part of phosphatidylinositol 3-kinase complex, class III, type I. Is expressed in adult head. Orthologous to human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vps15 in Genome Data Viewer
Location:
85D1-85D2; 3-48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9240757..9245869, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5066479..5071591, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pumilio Neighboring gene long non-coding RNA:CR45196 Neighboring gene uncharacterized protein Neighboring gene D1 chromosomal protein Neighboring gene Sulfotransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vps15 is required for stress induced and developmentally triggered autophagy and salivary gland protein secretion in Drosophila. Anding AL, et al. Cell Death Differ, 2015 Mar. PMID 25342466, Free PMC Article
  2. The PI 3-kinase regulator Vps15 is required for autophagic clearance of protein aggregates. Lindmo K, et al. Autophagy, 2008 May. PMID 18326940
  3. The multi-AT-hook chromosomal protein of Drosophila melanogaster, D1, is dispensable for viability. Weiler KS, et al. Genetics, 2009 May. PMID 19293138, Free PMC Article
  4. The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases. Powis KV, et al. Cell Signal, 2011 Jul. PMID 21385607
  5. Population genetic analysis of autophagy and phagocytosis genes in Drosophila melanogaster and D. simulans. Im JH, et al. PLoS One, 2018. PMID 30281656, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial structure maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment or maintenance of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in larval midgut cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in late endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus-vacuole junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphatidylinositol 3-kinase complex, class III, type I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vacuolar protein sorting 15
Names
CG9746-PA
CG9746-PB
CG9746-PC
Vps15-PA
Vps15-PB
Vps15-PC
immune response deficient 1
immune response-deficient 1
NP_001163565.1
NP_001262405.1
NP_649868.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9240757..9245869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141611.2 → NP_649868.1  vacuolar protein sorting 15, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHH2
    Related
    FBpp0081466
    Conserved Domains (6) summary
    smart00220
    Location:41 → 311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG2319
    Location:958 → 1342
    WD40; WD40 repeat [General function prediction only]
    cd13980
    Location:27 → 325
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:483 → 508
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1020 → 1063
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:953 → 1240
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001275476.1 → NP_001262405.1  vacuolar protein sorting 15, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262405.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGX5
    Conserved Domains (3) summary
    smart00220
    Location:41 → 311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13980
    Location:27 → 325
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:483 → 508
    HEAT; HEAT repeat [structural motif]

  3. NM_001170094.2 → NP_001163565.1  vacuolar protein sorting 15, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIG3
    Conserved Domains (3) summary
    smart00220
    Location:41 → 311
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13980
    Location:27 → 325
    STKc_Vps15; Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15
    sd00044
    Location:483 → 508
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGX5 A0A0B4KGX5
E1JIG3 E1JIG3
Q961J4 Q961J4
Q9VHH2 Q9VHH2

Gene LinkOut

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