U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAGEA11 MAGE family member A11 [ Homo sapiens (human) ]

Gene ID: 4110, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
MAGEA11provided by HGNC
Official Full Name
MAGE family member A11provided by HGNC
Primary source
HGNC:HGNC:6798
See related
Ensembl:ENSG00000185247 MIM:300344; AllianceGenome:HGNC:6798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT1.11; MAGE11; MAGE-11; MAGEA-11
Summary
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 1.8) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MAGEA11 in Genome Data Viewer
Location:
Xq28
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (149688193..149717268)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (147951770..147980829, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (148769859..148798928)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 185A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21045 Neighboring gene FRAXF repeat instability region Neighboring gene MAGE family member A11 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148757169-148757709 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:148808885-148809420 Neighboring gene MAGE family member A10 pseudogene Neighboring gene MAGE family member A11 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer. Farhadi L, et al. Gulf J Oncolog, 2023 Jan. PMID 36804154
  2. MAGE-11 protein is highly conserved in higher organisms and located predominantly in the nucleus. Jurk M, et al. Int J Cancer, 1998 Mar 2. PMID 9495246
  3. Hormone control and expression of androgen receptor coregulator MAGE-11 in human endometrium during the window of receptivity to embryo implantation. Bai S, et al. Mol Hum Reprod, 2008 Feb. PMID 18048459, Free PMC Article
  4. Increased expression of androgen receptor coregulator MAGE-11 in prostate cancer by DNA hypomethylation and cyclic AMP. Karpf AR, et al. Mol Cancer Res, 2009 Apr. PMID 19372581, Free PMC Article
  5. Expression of MAGE-A11 in breast cancer tissues and its effects on the proliferation of breast cancer cells. Xia LP, et al. Mol Med Rep, 2013 Jan. PMID 23064813

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer.
    Title: The Disruption of Mage-11 Gene via CRISPR/Cas9 Method Induced Apoptosis in the in vitro Model of Prostate Cancer.
  2. Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.
    Title: Molecular Characteristics of Bladder Tumor: Increased Gene Expression of MAGE-A6 and MAGE-A11 with Decreased MicroRNA-34a and MicroRNA-125b.
  3. Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
    Title: Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer.
  4. Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
    Title: Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
  5. Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
    Title: Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.
  6. High MAGE-A11 expression is associated with tumorigenesis.
    Title: A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.
  7. AR and MAGEA11 associate in a molecular complex.
    Title: Delayed endometrial decidualisation in polycystic ovary syndrome; the role of AR-MAGEA11.
  8. Significant up-regulation of melanoma-associated antigen-A11 was detected in esophageal cancer cell lines and esophageal squamous cell carcinoma tissues. Up-regulation of melanoma-associated antigen-A11 contributed to proliferation and invasion in cancer cells.
    Title: Demethylation-mediated upregulation of melanoma-associated antigen-A11 correlates with malignant progression of esophageal squamous cell carcinoma.
  9. MAGE-A11 and transcription factors SP1,TFCP2 and ZEB1 expression were associated with some clinical features in patients, such as pathological differentiation, tumor size, clinical stage, lymph node metastasis and distant metastasis. Patients with ESCC having high MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) expression had a worse prognosis compared to the patients with low expression.
    Title: Expression and prognostic significance of MAGE-A11 and transcription factors (SP1,TFCP2 and ZEB1) in ESCC tissues.
  10. SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity.
    Title: Androgen receptor regulation by histone methyltransferase Suppressor of variegation 3-9 homolog 2 and Melanoma antigen-A11.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC10511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
melanoma-associated antigen 11
Names
MAGE-11 antigen
cancer/testis antigen 1.11
cancer/testis antigen family 1, member 11
melanoma antigen family A, 11
melanoma antigen family A11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012803.2 RefSeqGene

    Range
    28869..34077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001011544.2 → NP_001011544.1  melanoma-associated antigen 11 isoform b

    See identical proteins and their annotated locations for NP_001011544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC244197, AI691089, BC004479, BX337921
    Consensus CDS
    CCDS94721.1
    UniProtKB/TrEMBL
    G5E962
    Related
    ENSP00000328177.4, ENST00000333104.8
    Conserved Domains (2) summary
    pfam01454
    Location:214 → 368
    MAGE; MAGE family
    pfam12440
    Location:86 → 175
    MAGE_N; Melanoma associated antigen family N terminal

  2. NM_005366.5 → NP_005357.2  melanoma-associated antigen 11 isoform a

    See identical proteins and their annotated locations for NP_005357.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC244098, AI691089, BC004479, BQ212898
    Consensus CDS
    CCDS48180.1
    UniProtKB/Swiss-Prot
    P43364, Q5ETU4, Q6ZRZ5
    Related
    ENSP00000347358.5, ENST00000355220.6
    Conserved Domains (2) summary
    pfam01454
    Location:243 → 397
    MAGE; MAGE family
    pfam12440
    Location:115 → 204
    MAGE_N; Melanoma associated antigen family N terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    149688193..149717268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442106.1 → XP_047298062.1  melanoma-associated antigen 11 isoform X1

    UniProtKB/Swiss-Prot
    P43364, Q5ETU4, Q6ZRZ5

  2. XM_011531164.3 → XP_011529466.1  melanoma-associated antigen 11 isoform X2

    Conserved Domains (2) summary
    pfam01454
    Location:235 → 389
    MAGE; MAGE family
    pfam12440
    Location:107 → 196
    MAGE_N; Melanoma associated antigen family N terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    147951770..147980829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327064.1 → XP_054183039.1  melanoma-associated antigen 11 isoform X1

    UniProtKB/Swiss-Prot
    P43364, Q5ETU4, Q6ZRZ5

  2. XM_054327065.1 → XP_054183040.1  melanoma-associated antigen 11 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43364.2 GenPept UniProtKB/Swiss-Prot:P43364

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools