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ATP6AP2 - ATPase H+ transporting accessory protein 2

Enables frizzled binding activity. Involved in several processes, including establishment of planar polarity; memory; and vacuolar proton-transporting V-type ATPase complex assembly. Located in several cellular components, including Golgi membrane; cell surface; and endoplasmic reticulum membrane. Part of vacuolar proton-transporting V-type ATPase complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; gut section; and organism subdivision. Used to study congenital disorder of glycosylation and syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in X-linked parkinsonism-spasticity syndrome; congenital disorder of glycosylation type II; and syndromic X-linked intellectual disability Hedera type. Orthologous to human ATP6AP2 (ATPase H+ transporting accessory protein 2). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa