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sage - salivary gland-expressed bHLH

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and salivary gland development. Located in chromatin. Is expressed in adult salivary gland; embryonic primordium of adult salivary gland; embryonic/larval salivary gland; embryonic/larval salivary gland body; and salivary gland body primordium. Human ortholog(s) of this gene implicated in myocardial infarction and spondylocostal dysostosis 2. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1); MESP2 (mesoderm posterior bHLH transcription factor 2); and MSGN1 (mesogenin 1). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa