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betaTub85D beta-Tubulin at 85D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41124, updated on 9-Dec-2024

Summary

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Official Symbol
betaTub85Dprovided by FlyBase
Official Full Name
beta-Tubulin at 85Dprovided by FlyBase
Primary source
FLYBASE:FBgn0003889
Locus tag
Dmel_CG9359
See related
AllianceGenome:FB:FBgn0003889
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2t; B2t; BETA 85D; beta(2)Tu; beta(2)Tub; beta-tub; beta-tub85D; beta-Tub85D; beta2; BETA2; beta2-tub; beta2t; beta2tub; beta85D; beta;Tub85D; betaTub; betaTub2; betatub85D; Betatub85D; BetaTub85D; betatubulin; beta[[2]]-tubulin; CG9359; D.m.BETA-85D; Dmbeta2; Dmel\CG9359; DTB4; FBgn0003889; ms(3)KK[D]; Tub; Tub2A; TUBB2A
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in salivary gland morphogenesis. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 5. Orthologous to human TUBB2A (tubulin beta 2A class IIa). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See betaTub85D in Genome Data Viewer
Location:
85D15-85D15; 3-48 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9408383..9410282, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5234105..5236004, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene BBSome interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene alpha-Mannosidase class II a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutation in a structural gene for a beta-tubulin specific to testis in Drosophila melanogaster. Kemphues KJ, et al. Proc Natl Acad Sci U S A, 1979 Aug. PMID 115008, Free PMC Article
  2. Mammalian DNMTs in the male germ line DNA of Drosophila. Weyrich A, et al. Biochem Cell Biol, 2008 Oct. PMID 18923539
  3. The proximal region of the beta-tubulin C-terminal tail is sufficient for axoneme assembly. Popodi EM, et al. Cell Motil Cytoskeleton, 2005 Sep. PMID 16080206
  4. The initiator element of the Drosophila beta2 tubulin gene core promoter contributes to gene expression in vivo but is not required for male germ-cell specific expression. Santel A, et al. Nucleic Acids Res, 2000 Mar 15. PMID 10684940, Free PMC Article
  5. Tissue-specific microtubule functions in Drosophila spermatogenesis require the beta 2-tubulin isotype-specific carboxy terminus. Fackenthal JD, et al. Dev Biol, 1993 Jul. PMID 8330671

See all (220) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta2t plays an important role in salivary gland and myoblast migration
    Title: Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo.
  2. Partially truncated beta2-tubulin (beta2Delta7) containing only the proximal portion of the C-terminal tail, including the axoneme motif, can support production of functional motile sperm.
    Title: The proximal region of the beta-tubulin C-terminal tail is sufficient for axoneme assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in salivary gland morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-Tubulin at 85D
Names
CG9359-PA
b2 tubulin
beta 2 tubulin
beta tubulin
beta(2)Tubulin
beta-Tubulin
beta-Tubulin 85D
beta-tubulin85D
beta2 tubulin
beta2-tubulin
beta2tubulin
betaTub85D-PA
betaTubulin85D
testis-specific beta-tubulin
tubulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9408383..9410282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079566.4 → NP_524290.2  beta-Tubulin at 85D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524290.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P61857, Q540X8
    UniProtKB/TrEMBL
    E0R982
    Related
    FBpp0081524
    Conserved Domains (1) summary
    PLN00220
    Location:1 → 430
    PLN00220; tubulin beta chain; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61857.1 P61857

Gene LinkOut

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