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Dhc1 Dynein heavy chain 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41171, updated on 4-Jan-2025

Summary

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Official Symbol
Dhc1provided by FlyBase
Official Full Name
Dynein heavy chain 1provided by FlyBase
Primary source
FLYBASE:FBgn0287844
Locus tag
Dmel_CG9492
See related
AllianceGenome:FB:FBgn0287844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9492; DHC3B; DmDhc1; Dmel\CG9492; dnah5; Dnah5
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in sensory perception of sound. Predicted to be part of outer dynein arm. Predicted to be active in 9+2 motile cilium. Is expressed in antenna; chordotonal neurons; and spermatozoon. Used to study sensorineural hearing loss. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Dhc1 in Genome Data Viewer
Location:
85E2-85E3; 3-49 cM
Exon count:
37
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9651179..9674643, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5476901..5500365, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Spermidine Synthase Neighboring gene Sex comb on midleg Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Neprilysin-like 12 Neighboring gene p23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Axonemal Dynein DNAH5 is Required for Sound Sensation in Drosophila Larvae. Li B, et al. Neurosci Bull, 2021 Apr. PMID 33570705, Free PMC Article
  2. The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. Cabrero P, et al. J Exp Biol, 2002 Dec. PMID 12432004
  3. The Krüppel-Like Factor Dar1 Determines Multipolar Neuron Morphology. Wang X, et al. J Neurosci, 2015 Oct 21. PMID 26490864, Free PMC Article
  4. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
  5. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in 9+2 motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of outer dynein arm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein heavy chain 1
Names
CG9492-PD
CG9492-PE
CG9492-PF
CG9492-PG
Dhc1-PD
Dhc1-PE
Dhc1-PF
Dhc1-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9651179..9674643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260079.2 → NP_001247008.1  dynein heavy chain 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247008.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K648
    Conserved Domains (7) summary
    COG5245
    Location:1178 → 4348
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:4007 → 4689
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:283 → 843
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1458 → 1861
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3276 → 3622
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3650 → 3866
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1994 → 2222
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001300327.1 → NP_001287256.1  dynein heavy chain 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LH20
    Conserved Domains (7) summary
    COG5245
    Location:1178 → 4372
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:4031 → 4713
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:283 → 843
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1458 → 1861
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3300 → 3646
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3674 → 3890
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1994 → 2222
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_141666.5 → NP_649923.4  dynein heavy chain 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649923.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH97
    Conserved Domains (7) summary
    COG5245
    Location:1170 → 4340
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:3999 → 4681
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:254 → 814
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1450 → 1853
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3268 → 3614
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3642 → 3858
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1986 → 2214
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001260078.2 → NP_001247007.1  dynein heavy chain 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247007.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K614
    Conserved Domains (7) summary
    COG5245
    Location:1170 → 4364
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam03028
    Location:4023 → 4705
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:254 → 814
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1450 → 1853
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3292 → 3638
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3666 → 3882
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:1986 → 2214
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K614 A0A0B4K614
A0A0B4K648 A0A0B4K648
A0A0B4LH20 A0A0B4LH20
Q9VH97 Q9VH97

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