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Nepl12 Neprilysin-like 12 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41172, updated on 9-Dec-2024

Summary

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Official Symbol
Nepl12provided by FlyBase
Official Full Name
Neprilysin-like 12provided by FlyBase
Primary source
FLYBASE:FBgn0037727
Locus tag
Dmel_CG8358
See related
AllianceGenome:FB:FBgn0037727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8358; Dmel\CG8358
Summary
Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in distal arthrogryposis type 5D. Orthologous to human ECEL1 (endothelin converting enzyme like 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Nepl12 in Genome Data Viewer
Location:
85E3-85E3; 3-49 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9675523..9677778)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5501245..5503500)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Diuretic hormone 44 Neighboring gene Frost Neighboring gene pseudo Neighboring gene Dynein heavy chain 1 Neighboring gene nmdyn-D7 Neighboring gene p23 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. New genes in Drosophila quickly become essential. Chen S, et al. Science, 2010 Dec 17. PMID 21164016, Free PMC Article
  2. Identification and bioinformatic analysis of neprilysin and neprilysin-like metalloendopeptidases in Drosophila melanogaster. Meyer H, et al. MicroPubl Biol, 2021 Jun 23. PMID 34189422, Free PMC Article
  3. Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis. Lebo MS, et al. BMC Genomics, 2009 Feb 13. PMID 19216785, Free PMC Article
  4. Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships. Bland ND, et al. BMC Evol Biol, 2008 Jan 23. PMID 18215274, Free PMC Article
  5. Tumour-host interactions through the lens of Drosophila. Bilder D, et al. Nat Rev Cancer, 2021 Nov. PMID 34389815, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Neprilysin-like 12
Names
CG8358-PA
Nepl12-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9675523..9677778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141667.3 → NP_649924.1  Neprilysin-like 12 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VH96
    Related
    FBpp0081559
    Conserved Domains (1) summary
    cd08662
    Location:68 → 700
    M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VH96 Q9VH96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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