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Unc-115b Uncoordinated 115b [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41178, updated on 4-Jan-2025

Summary

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Official Symbol
Unc-115bprovided by FlyBase
Official Full Name
Uncoordinated 115bprovided by FlyBase
Primary source
FLYBASE:FBgn0260463
Locus tag
Dmel_CG31332
See related
AllianceGenome:FB:FBgn0260463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.9; CG31332; CG9489; Dmel\CG31332; unc-115
Old locus tag
CG31332
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in lamellipodium assembly. Located in nucleoplasm. Is expressed in several structures, including adult brain cell body rind; adult head; brain; embryonic hindgut; and epithelium. Orthologous to human ABLIM1 (actin binding LIM protein 1); ABLIM2 (actin binding LIM protein family member 2); and ABLIM3 (actin binding LIM protein family member 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See Unc-115b in Genome Data Viewer
Location:
85E4-85E4; 3-49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9687060..9692775, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5512782..5518497, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene nmdyn-D7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eclair Neighboring gene p24-related-2 Neighboring gene uncharacterized protein Neighboring gene Uncoordinated 115a Neighboring gene trabid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional analysis of actin-binding proteins in the central nervous system of Drosophila. He Q. Methods Mol Biol, 2009. PMID 19768442
  2. Role of Drosophila gene dunc-115 in nervous system. Garcia MC, et al. Invert Neurosci, 2007 Jun. PMID 17505850
  3. Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons. Jetti SK, et al. Neuron, 2023 Nov 15. PMID 37611584
  4. Transcriptome Analysis of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity. Moskalev AA, et al. Sci Rep, 2019 Jun 24. PMID 31235842, Free PMC Article
  5. Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster. Hartmann B, et al. RNA, 2011 Mar. PMID 21233220, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm HDA PubMed 

General protein information

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Preferred Names
uncoordinated 115b
Names
CG31332-PA
CG31332-PB
CG31332-PC
CG31332-PD
CG31332-PE
CG31332-PF
Unc-115b-PA
Unc-115b-PB
Unc-115b-PC
Unc-115b-PD
Unc-115b-PE
Unc-115b-PF
unc-115

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9687060..9692775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169300.2 → NP_731389.2  uncoordinated 115b, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731389.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH19, Q8INN7
    Related
    FBpp0081575, FBtr0082097
    Conserved Domains (4) summary
    cd09327
    Location:41 → 92
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:97 → 152
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:206 → 257
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:265 → 321
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  2. NM_169302.1 → NP_731391.1  uncoordinated 115b, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY10, Q95NJ1, Q9VH92
    Related
    FBpp0081573, FBtr0082095
    Conserved Domains (4) summary
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:195 → 246
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:254 → 310
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  3. NM_001202275.2 → NP_001189204.1  uncoordinated 115b, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189204.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY10, Q95NJ1, Q9VH92
    Conserved Domains (4) summary
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:195 → 246
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:254 → 310
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  4. NM_169301.3 → NP_731390.1  uncoordinated 115b, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731390.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E8NH01, Q8INN6
    Related
    FBpp0081572
    Conserved Domains (4) summary
    cd09327
    Location:46 → 97
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:102 → 157
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:211 → 262
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:270 → 326
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  5. NM_001316571.1 → NP_001303500.1  uncoordinated 115b, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUR5, C4IY10
    Conserved Domains (4) summary
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:195 → 246
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:254 → 310
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins

  6. NM_169303.3 → NP_731392.2  uncoordinated 115b, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731392.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY10, Q8INN5
    Related
    FBpp0081574
    Conserved Domains (4) summary
    cd09327
    Location:30 → 81
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:86 → 141
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:195 → 246
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:254 → 310
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A126GUR5 A0A126GUR5
Q8INN5 Q8INN5
Q8INN6 Q8INN6
Q8INN7 Q8INN7
Q95V19 Q95V19
Q9VH92 Q9VH92

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