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side-VII sidestep VII [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41184, updated on 9-Dec-2024

Summary

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Official Symbol
side-VIIprovided by FlyBase
Official Full Name
sidestep VIIprovided by FlyBase
Primary source
FLYBASE:FBgn0037736
Locus tag
Dmel_CG12950
See related
AllianceGenome:FB:FBgn0037736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
12950; CG12950; CT32101; Dmel\CG12950
Summary
Enables cell adhesion receptor activity. Involved in synapse assembly. Is active in presynaptic membrane. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval tracheal dorsal trunk; ganglia; and larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See side-VII in Genome Data Viewer
Location:
85E6-85E6; 3-49 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9734012..9739979, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5559734..5565701, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Forkhead box P Neighboring gene alpha-Tubulin at 85E Neighboring gene Pinin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Searching for guidance cues: follow the Sidestep trail. Aberle H. Fly (Austin), 2009 Oct-Dec. PMID 19786838
  2. Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity. Osaka J, et al. Cell Rep, 2024 Feb 27. PMID 38381608
  3. Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development. Li H, et al. Elife, 2017 Aug 15. PMID 28829740, Free PMC Article
  4. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Özkan E, et al. Cell, 2013 Jul 3. PMID 23827685, Free PMC Article
  5. The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity. Vogel C, et al. Development, 2003 Dec. PMID 14623821

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sidestep VII
Names
CG12950-PA
CG12950-PB
side-VII-PA
side-VII-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9734012..9739979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275503.1 → NP_001262432.1  sidestep VII, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262432.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0P8, Q9VH85
    Conserved Domains (7) summary
    smart00408
    Location:360 → 425
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:32 → 134
    IG_like; Immunoglobulin like
    cd00063
    Location:538 → 620
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:32 → 134
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:456 → 519
    Ig_3; Immunoglobulin domain
    pfam14851
    Location:643 → 741
    FAM176; FAM176 family
    cl11960
    Location:262 → 328
    Ig; Immunoglobulin domain

  2. NM_141676.3 → NP_649933.1  sidestep VII, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0P8, Q9VH85
    Related
    FBpp0081648
    Conserved Domains (7) summary
    smart00408
    Location:360 → 425
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:32 → 134
    IG_like; Immunoglobulin like
    cd00063
    Location:538 → 620
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:32 → 134
    V-set; Immunoglobulin V-set domain
    pfam13927
    Location:456 → 519
    Ig_3; Immunoglobulin domain
    pfam14851
    Location:643 → 741
    FAM176; FAM176 family
    cl11960
    Location:262 → 328
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VH85 Q9VH85

Gene LinkOut

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