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Pnn Pinin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41185, updated on 9-Dec-2024

Summary

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Official Symbol
Pnnprovided by FlyBase
Official Full Name
Pininprovided by FlyBase
Primary source
FLYBASE:FBgn0037737
Locus tag
Dmel_CG8383
See related
AllianceGenome:FB:FBgn0037737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8383; Dmel\CG8383; dPnn; FBgn0037737
Summary
Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in dorsal pharyngeal muscle primordium; head visceral muscle primordium; organism; somatic muscle primordium; and visceral muscle primordium. Orthologous to human PNN (pinin, desmosome associated protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Pnn in Genome Data Viewer
Location:
85E6-85E6; 3-49 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9740899..9742844)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5566621..5568566)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene alpha-Tubulin at 85E Neighboring gene sidestep VII Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila dSAP18 is a nuclear protein that associates with chromosomes and the nuclear matrix, and interacts with pinin, a protein factor involved in RNA splicing. Costa E, et al. Chromosome Res, 2006. PMID 16823614
  2. The structure of the ASAP core complex reveals the existence of a Pinin-containing PSAP complex. Murachelli AG, et al. Nat Struct Mol Biol, 2012 Mar 4. PMID 22388736
  3. The exon junction complex: a splicing factor for long intron containing transcripts? Ashton-Beaucage D, et al. Fly (Austin), 2011 Jul-Sep. PMID 21478676
  4. The Y Chromosome Modulates Splicing and Sex-Biased Intron Retention Rates in Drosophila. Wang M, et al. Genetics, 2018 Mar. PMID 29263027, Free PMC Article
  5. Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly. Barbosa I, et al. Nat Struct Mol Biol, 2012 Oct. PMID 22961380

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
pinin
Names
CG8383-PA
CG8383-PB
Pnn-PA
Pnn-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9740899..9742844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104257.2 → NP_001097727.1  pinin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097727.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JQW3, Q8IFW3
    Conserved Domains (1) summary
    pfam04696
    Location:126 → 250
    Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region

  2. NM_141677.3 → NP_649934.1  pinin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649934.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IFW3, Q9VH84
    Related
    FBpp0081604
    Conserved Domains (1) summary
    pfam04696
    Location:126 → 250
    Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JQW3 A8JQW3
Q8IFW3 Q8IFW3
Q9VH84 Q9VH84

Gene LinkOut

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