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Art4 Arginine methyltransferase 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41219, updated on 9-Dec-2024

Summary

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Official Symbol
Art4provided by FlyBase
Official Full Name
Arginine methyltransferase 4provided by FlyBase
Primary source
FLYBASE:FBgn0037770
Locus tag
Dmel_CG5358
See related
AllianceGenome:FB:FBgn0037770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CARM1; CG5358; dArt 4; Dart4; DART4; Dmel\CG5358; PRMT4
Summary
Enables histone methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; and protein-arginine omega-N monomethyltransferase activity. Involved in positive regulation of ecdysone receptor signaling pathway and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Part of histone methyltransferase complex. Is expressed in several structures, including embryonic/larval midgut primordium; female germline cell; ganglia; head epidermis primordium; and imaginal disc. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Art4 in Genome Data Viewer
Location:
85F4-85F4; 3-49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9982816..9986060, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5808538..5811782, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tipE homolog 1 Neighboring gene long non-coding RNA:CR45029 Neighboring gene uncharacterized protein Neighboring gene Glucose transporter 4 enhancer factor Neighboring gene mir-9371 stem loop Neighboring gene Gustatory receptor 85a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tissue-dependent subcellular localization of Drosophila arginine methyl-transferase 4 (DART4), a coactivator whose overexpression affects neither viability nor differentiation. Urwyler O, et al. Differentiation, 2007 Oct. PMID 17459088
  2. Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor. Kimura S, et al. Biochem Biophys Res Commun, 2008 Jul 11. PMID 18468516
  3. LKRSDH-dependent histone modifications of insulin-like peptide sites contribute to age-related circadian rhythm changes. Lv P, et al. Nat Commun, 2024 Apr 18. PMID 38637528, Free PMC Article
  4. The lncRNA hsrω regulates arginine dimethylation of human FUS to cause its proteasomal degradation in Drosophila. Lo Piccolo L, et al. J Cell Sci, 2019 Oct 23. PMID 31519807, Free PMC Article
  5. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3R17 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H3R2 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3R2 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-arginine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ecdysone receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arginine methyltransferase 4
Names
Art4-PA
Art4-PB
CARMER
CG5358-PA
CG5358-PB
arginie methyl transferase 4
arginine methyl-transferase 4
coactivator Arg methyltransferase for Ecr/Usp
NP_001262445.1
NP_649963.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    9982816..9986060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275516.1 → NP_001262445.1  arginine methyltransferase 4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NL6, Q9VH48
    UniProtKB/TrEMBL
    F0JAI1
    Conserved Domains (3) summary
    cd02440
    Location:183 → 281
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05185
    Location:53 → 430
    PRMT5; PRMT5 arginine-N-methyltransferase
    cl17171
    Location:24 → 134
    PH-like; Pleckstrin homology-like domain

  2. NM_141706.3 → NP_649963.1  arginine methyltransferase 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_649963.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NL6, Q9VH48
    UniProtKB/TrEMBL
    F0JAI1
    Related
    FBpp0081628
    Conserved Domains (3) summary
    cd02440
    Location:183 → 281
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    pfam05185
    Location:53 → 430
    PRMT5; PRMT5 arginine-N-methyltransferase
    cl17171
    Location:24 → 134
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F0JAI1 F0JAI1
Q9VH48.1 Q9VH48

Gene LinkOut

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