Syn Synapsin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Synprovided by FlyBase
Official Full Name: Synapsinprovided by FlyBase
Primary source: FLYBASE:FBgn0004575
Locus tag: Dmel_CG3985
See related: AllianceGenome:FB:FBgn0004575
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3985; Dmel\CG3985; Dsyn-1; syn; SYN; SYN1; SYN2; synapsin
Summary: Predicted to enable ATP binding activity. Involved in several processes, including behavioral response to ethanol; learning or memory; and synapse organization. Located in terminal bouton. Is expressed in adult head; embryonic ventral epidermis; ganglia; lamina; and outer photoreceptor cell. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders; non-syndromic X-linked intellectual disability 50; and schizophrenia. Orthologous to several human genes including SYN3 (synapsin III). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 85F16-86A1; 3-49 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10190689..10222442)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6016411..6048164)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
Title: Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila.
We show that after odor-high salt conditioning larvae form two parallel memory phases; a short lasting component that depends on cyclic adenosine 3'5'-monophosphate (cAMP) signaling and synapsin gene function
Title: Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.
Synapsin is required for short- but not longer-term memory.
Title: Synapsin is required to "boost" memory strength for highly salient events.
This study report Synapsin as a determinant for memory strength in a behavioral assay of timing-dependent associative plasticity.
Title: Synapsin determines memory strength after punishment- and relief-learning.
the Tango-Trace strategy we used may be applied more generally to identify neural circuits in the fly brain
Title: Identifying functional connections of the inner photoreceptors in Drosophila using Tango-Trace.
This study demonistrated that support a model whereby synapsin accumulates at sites of synaptic growth and facilitates budding of new boutons via a cAMP/PKA-dependent pathway.
Title: Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.
these data support a model in which CaMKII-mediated synapsin phosphorylation in local circuit interneurons induces synaptic vesicle mobilization and thereby presynaptic facilitation of GABA release that underlies olfactory short-term habituation.
Title: Synapsin function in GABA-ergic interneurons is required for short-term olfactory habituation.
This study synapsin acts in associative memory trace formation in the mushroom bodies, as a downstream element of AC-cAMP-PKA signaling.
Title: Cellular site and molecular mode of synapsin action in associative learning.
these results elucidate a novel synapsin function, specifically, promoting vesicle reuptake and reserve pool formation upon intense stimulation.
Title: Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons.
synapsin maintains the reserve pool of vesicles and segregation between the recycling and reserve pools
Title: Synapsin maintains the reserve vesicle pool and spatial segregation of the recycling pool in Drosophila presynaptic boutons.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 10197007-10202936 mobile_element_type = transposon:297{}1282

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IEA Inferred from Electronic Annotation more info
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optomotor response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: synapsin

Names: CG3985-PA; CG3985-PD; CG3985-PE; CG3985-PF; Syn-PA; Syn-PD; Syn-PE; Syn-PF; Synapsin1; synapsin I

NP_731458.2

non-AUG (CUG) translation initiation

NP_731459.2

non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

10190689..10222442

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169333.3 → NP_731458.2 synapsin, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731458.2

Status: REVIEWED

UniProtKB/TrEMBL

E2QCZ0, Q5BIE8

Conserved Domains (3) summary

pfam02078
Location:151 → 246

Synapsin; Synapsin, N-terminal domain

pfam05350
Location:427 → 543

GSK-3_bind; Glycogen synthase kinase-3 binding

cl17255
Location:248 → 452

ATP-grasp_4; ATP-grasp domain
NM_176451.3 → NP_788628.2 synapsin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788628.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24544, Q24545, Q24546, Q86BA0, Q8INM4, Q8INM6

Related

FBpp0088481

Conserved Domains (3) summary

pfam02078
Location:91 → 186

Synapsin; Synapsin, N-terminal domain

pfam05350
Location:367 → 483

GSK-3_bind; Glycogen synthase kinase-3 binding

cl17255
Location:188 → 392

ATP-grasp_4; ATP-grasp domain
NM_169334.3 → NP_731459.2 synapsin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731459.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24544, Q24545, Q24546, Q86BA0, Q8INM4, Q8INM6

UniProtKB/TrEMBL

E2QCY9

Conserved Domains (3) summary

pfam02078
Location:151 → 246

Synapsin; Synapsin, N-terminal domain

pfam05350
Location:427 → 543

GSK-3_bind; Glycogen synthase kinase-3 binding

cl17255
Location:248 → 452

ATP-grasp_4; ATP-grasp domain
NM_169332.4 → NP_731457.2 synapsin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731457.2

Status: REVIEWED

UniProtKB/TrEMBL

Q5BIE8

Conserved Domains (3) summary

pfam02078
Location:91 → 186

Synapsin; Synapsin, N-terminal domain

pfam05350
Location:367 → 483

GSK-3_bind; Glycogen synthase kinase-3 binding

cl17255
Location:188 → 392

ATP-grasp_4; ATP-grasp domain