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hth homothorax [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41273, updated on 9-Dec-2024

Summary

Official Symbol
hthprovided by FlyBase
Official Full Name
homothoraxprovided by FlyBase
Primary source
FLYBASE:FBgn0001235
Locus tag
Dmel_CG17117
See related
AllianceGenome:FB:FBgn0001235
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1323/07; 1422/04; anon-EST:Liang-2.13; CG17117; clone 2.13; Dm-HTH; Dmel\CG17117; dtl; Hth; HTH; hth1; hth2; l(3)05745; l(3)86Ca; Meis1; MEIS1; P53
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and transcription coactivator binding activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; nervous system development; and positive regulation of cell proliferation involved in compound eye morphogenesis. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex and protein-DNA complex. Is expressed in several structures, including germ layer; imaginal disc; organism subdivision; segmental subdivision of organ system; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in cleft palate; cleft palate, cardiac defects, and intellectual disabillity; learning disability; open-angle glaucoma; and orofacial cleft. Orthologous to several human genes including MEIS1 (Meis homeobox 1) and MEIS3 (Meis homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See hth in Genome Data Viewer
Location:
86C1-86C3; 3-50 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10507561..10639568, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6333283..6465290, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44955 Neighboring gene long non-coding RNA:CR45576 Neighboring gene mir-4944 stem loop Neighboring gene antisense RNA:CR44018 Neighboring gene uncharacterized protein Neighboring gene Phytanoyl-CoA dioxygenase domain containing 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Malpighian tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye photoreceptor fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in haltere morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in head morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oenocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell proliferation involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in proximal/distal pattern formation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in salivary gland boundary specification TAS
Traceable Author Statement
more info
PubMed 
involved_in segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of animal organ identity TAS
Traceable Author Statement
more info
PubMed 
involved_in specification of segmental identity, antennal segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of segmental identity, head IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
homothorax
Names
CG17117-PA
CG17117-PC
CG17117-PE
CG17117-PF
CG17117-PI
dorsotonals
gene II
hth-PA
hth-PC
hth-PE
hth-PF
hth-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    10507561..10639568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057228.5NP_476576.1  homothorax, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476576.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17427, O46339, Q058V1, Q4AB34, Q59DX7, Q6NR42, Q7KQ21, Q8INL5, Q8INL6, Q9VGY9
    Related
    FBpp0081732
    Conserved Domains (2) summary
    pfam05920
    Location:383422
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:127211
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  2. NM_057230.6NP_476578.3  homothorax, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476578.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46339
    Conserved Domains (2) summary
    pfam05920
    Location:368407
    Homeobox_KN; Homeobox KN domain
    pfam16493
    Location:127211
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  3. NM_057229.5NP_476577.3  homothorax, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476577.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46339
    Conserved Domains (1) summary
    pfam16493
    Location:127210
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  4. NM_001014613.3NP_001014613.2  homothorax, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014613.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    J7HAH8
    Conserved Domains (1) summary
    pfam16493
    Location:127211
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
  5. NM_001031999.2NP_001027170.1  homothorax, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001027170.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46339
    Conserved Domains (1) summary
    pfam16493
    Location:127210
    Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1