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MAOB monoamine oxidase B [ Homo sapiens (human) ]

Gene ID: 4129, updated on 27-Nov-2024

Summary

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Official Symbol
MAOBprovided by HGNC
Official Full Name
monoamine oxidase Bprovided by HGNC
Primary source
HGNC:HGNC:6834
See related
Ensembl:ENSG00000069535 MIM:309860; AllianceGenome:HGNC:6834
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
Expression
Broad expression in liver (RPKM 72.6), ovary (RPKM 62.8) and 18 other tissues See more
Orthologs
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Genomic context

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See MAOB in Genome Data Viewer
Location:
Xp11.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (43766610..43882450, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (43172827..43288647, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (43625857..43741696, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene MPRA-validated peak7375 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:43309398-43310202 Neighboring gene MPRA-validated peak7376 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chrX:43514055-43514449 Neighboring gene monoamine oxidase A Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43808655-43809172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43809173-43809689 Neighboring gene NDP antisense RNA 1 Neighboring gene norrin cystine knot growth factor NDP Neighboring gene RBM39 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A meta-analysis on relationship of MAOB intron 13 polymorphisms, interactions with smoking/COMT H158L polymorphisms with the risk of PD. Zhang Y, et al. Int J Neurosci, 2016. PMID 26000819
  2. [MAOB: a modifier gene in phenylketonuria?]. Ghozlan A, et al. Med Sci (Paris), 2004 Oct. PMID 15461973
  3. The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis. Liu Y, et al. Ann Saudi Med, 2014 Jan-Feb. PMID 24658549, Free PMC Article
  4. Perspectives on MAO-B in aging and neurological disease: where do we go from here? Kumar MJ, et al. Mol Neurobiol, 2004 Aug. PMID 15247489
  5. Platelet monoamine oxidase activity in subjects tested for Huntington's disease gene mutation. Markianos M, et al. J Neural Transm (Vienna), 2004 Apr. PMID 15057517

See all (210) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Monoamine oxidase B inhibits epithelial-mesenchymal transition and trigger apoptosis via targeting ERK1/2 signaling pathway in head and neck squamous cell carcinoma.
    Title: Monoamine oxidase B inhibits epithelial-mesenchymal transition and trigger apoptosis via targeting ERK1/2 signaling pathway in head and neck squamous cell carcinoma.
  2. MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease.
    Title: MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease.
  3. Stromal-derived MAOB promotes prostate cancer growth and progression.
    Title: Stromal-derived MAOB promotes prostate cancer growth and progression.
  4. Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma.
    Title: Platelet Serotonin (5-HT) Concentration, Platelet Monoamine Oxidase B (MAO-B) Activity and HTR2A, HTR2C, and MAOB Gene Polymorphisms in Asthma.
  5. Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
    Title: Relationship of DRD5 and MAO-B VNTR polymorphisms with paranoid and antisocial personality disorders in polydrug users.
  6. Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD.
    Title: Reduced Platelet MAO-B Activity Is Associated with Psychotic, Positive, and Depressive Symptoms in PTSD.
  7. Revisiting the Role of Astrocytic MAOB in Parkinson's Disease.
    Title: Revisiting the Role of Astrocytic MAOB in Parkinson's Disease.
  8. Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE epsilon4 Allele in Alzheimer's Disease.
    Title: Association of the MAOB rs1799836 Single Nucleotide Polymorphism and APOE ε4 Allele in Alzheimer's Disease.
  9. Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model.
    Title: Inhibition of monoamine oxidase B prevents reactive astrogliosis and scar formation in stab wound injury model.
  10. Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step.
    Title: Why Monoamine Oxidase B Preferably Metabolizes N-Methylhistamine over Histamine: Evidence from the Multiscale Simulation of the Rate-Limiting Step.
Submit: New GeneRIF Correction See all GeneRIFs (138)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC26382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity TAS
Traceable Author Statement
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables monoamine oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables primary methylamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables primary methylamine oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables primary methylamine oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dopamine catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in hydrogen peroxide biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of serotonin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylethylamine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dopamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to aluminum ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to corticosterone IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in response to selenium ion IEA
Inferred from Electronic Annotation
more info
  
involved_in response to toxic substance IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
amine oxidase [flavin-containing] B
Names
MAO, brain
MAO, platelet
MAO-B
adrenalin oxidase
monoamine oxidase type B
tyramine oxidase
NP_000889.3
XP_016885013.1
XP_054183044.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008723.2 RefSeqGene

    Range
    5026..120866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000898.5 → NP_000889.3  amine oxidase [flavin-containing] B

    See identical proteins and their annotated locations for NP_000889.3

    Status: REVIEWED

    Source sequence(s)
    AL133791, BM726427, DC326844, M69177
    Consensus CDS
    CCDS14261.1
    UniProtKB/Swiss-Prot
    B2R6R3, B7Z5H3, D3DWC3, P27338, Q7Z6S2
    UniProtKB/TrEMBL
    Q8TBI1
    Related
    ENSP00000367309.4, ENST00000378069.5
    Conserved Domains (1) summary
    pfam01593
    Location:14 → 451
    Amino_oxidase; Flavin containing amine oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    43766610..43882450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029524.3 → XP_016885013.1  amine oxidase [flavin-containing] B isoform X1

    UniProtKB/TrEMBL
    B7Z242, Q8TBI1
    Conserved Domains (2) summary
    pfam01593
    Location:1 → 435
    Amino_oxidase; Flavin containing amine oxidoreductase
    pfam13450
    Location:1 → 59
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    43172827..43288647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327069.1 → XP_054183044.1  amine oxidase [flavin-containing] B isoform X1

    UniProtKB/TrEMBL
    B7Z242
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27338.3 GenPept UniProtKB/Swiss-Prot:P27338

Gene LinkOut

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