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cu curled [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41339, updated on 9-Dec-2024

Summary

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Official Symbol
cuprovided by FlyBase
Official Full Name
curledprovided by FlyBase
Primary source
FLYBASE:FBgn0261808
Locus tag
Dmel_CG31299
See related
AllianceGenome:FB:FBgn0261808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31299; CG4782; CG4796; Dmel\CG31299; no; no(cu); noc; noct; Noct; nocturnin
Summary
Enables NADP phosphatase activity and NADPH phosphatase activity. Involved in NADP metabolic process; locomotor rhythm; and response to light stimulus. Located in cytoplasm. Is expressed in several structures, including DN3 neuron; adult brain; adult head; embryonic/larval salivary gland; and gut section. Orthologous to human NOCT (nocturnin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
86D7-86D7; 3-50 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11197592..11208633)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7023314..7034355)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene UDP-glycosyltransferase family 303 member A1 Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit C Neighboring gene Translationally controlled tumor protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Malformed, a mutation of Drosophila melanogaster producing mirror-image duplication of a portion of the orbit. Baker WK, et al. Dev Biol, 1977 May. PMID 405263
  2. The metabolites NADP(+) and NADPH are the targets of the circadian protein Nocturnin (Curled). Estrella MA, et al. Nat Commun, 2019 May 30. PMID 31147539, Free PMC Article
  3. seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye. Carthew RW, et al. Cell, 1990 Nov 2. PMID 2146028
  4. A gene responsible for a cuticular hydrocarbon polymorphism in Drosophila melanogaster. Coyne JA, et al. Genet Res, 1999 Jun. PMID 10425916
  5. Cytogenetic localization by variation in electrophoretic allozyme phenotype: Drosophila Odh. Clark BA. Biochem Genet, 1983 Apr. PMID 6407472

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADP phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
curled
Names
CG31299-PC
CG31299-PD
CG31299-PE
CG31299-PF
CG31299-PG
CG31299-PH
cu-PC
cu-PD
cu-PE
cu-PF
cu-PG
cu-PH
dnocturnin
nocturin
nocturnin
NP_001097745.1
NP_001097746.1
NP_001097747.1
NP_001262471.1
NP_731539.2
NP_731540.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11197592..11208633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169375.2 → NP_731540.2  curled, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731540.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PPK5
    Conserved Domains (1) summary
    cl00490
    Location:111 → 408
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_169374.2 → NP_731539.2  curled, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731539.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0C4DHA6
    Conserved Domains (1) summary
    cl00490
    Location:151 → 448
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  3. NM_001104277.2 → NP_001097747.1  curled, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q3ZAP4
    Conserved Domains (1) summary
    cl00490
    Location:116 → 413
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  4. NM_001275542.1 → NP_001262471.1  curled, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262471.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH43
    Conserved Domains (1) summary
    cl00490
    Location:89 → 386
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  5. NM_001104276.2 → NP_001097746.1  curled, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097746.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A0B4KH43, A0A0C4DHA6, A8JQX3, C0PPK5, Q3ZAP4, Q6AWF6, Q8MTZ6
    Conserved Domains (1) summary
    cl00490
    Location:312 → 609
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  6. NM_001104275.3 → NP_001097745.1  curled, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097745.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MTZ6
    Conserved Domains (1) summary
    cl00490
    Location:119 → 416
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8JQX3.1 A8JQX3

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