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dpr5 defective proboscis extension response 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41381, updated on 2-Nov-2024

Summary

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Official Symbol
dpr5provided by FlyBase
Official Full Name
defective proboscis extension response 5provided by FlyBase
Primary source
FLYBASE:FBgn0037908
Locus tag
Dmel_CG5308
See related
AllianceGenome:FB:FBgn0037908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5308; CT16895; Dmel\CG5308; Dpr-5; Dpr5
Summary
Involved in synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dpr5 in Genome Data Viewer
Location:
86E7-86E8; 3-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11499984..11505951)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7325706..7331673)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein LB Neighboring gene long non-coding RNA:CR45581 Neighboring gene antisense RNA:CR45056 Neighboring gene defective proboscis extension response 4 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila. Pérez-Moreno JJ, et al. G3 (Bethesda), 2019 Feb 7. PMID 30530644, Free PMC Article
  2. The autophagy protein Def8 is altered in Alzheimer's disease and Aβ42-expressing Drosophila brains. Oyarce-Pezoa S, et al. Sci Rep, 2023 Oct 10. PMID 37816871, Free PMC Article
  3. Transneuronal Dpr12/DIP-δ interactions facilitate compartmentalized dopaminergic innervation of Drosophila mushroom body axons. Bornstein B, et al. EMBO J, 2021 Jun 15. PMID 33847376, Free PMC Article
  4. Constraints, independence, and evolution of thermal plasticity: probing genetic architecture of long- and short-term thermal acclimation. Gerken AR, et al. Proc Natl Acad Sci U S A, 2015 Apr 7. PMID 25805817, Free PMC Article
  5. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. Barish S, et al. PLoS Genet, 2018 Aug. PMID 30102700, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sensory perception of chemical stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuron projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
defective proboscis extension response 5
Names
CG5308-PA
CG5308-PB
dpr5-PA
dpr5-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11499984..11505951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141823.3 → NP_650080.3  defective proboscis extension response 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650080.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961T8, Q9VGN0
    Related
    FBpp0081870
    Conserved Domains (3) summary
    cd00096
    Location:211 → 278
    Ig; Immunoglobulin domain
    smart00410
    Location:206 → 278
    IG_like; Immunoglobulin like
    pfam07686
    Location:95 → 191
    V-set; Immunoglobulin V-set domain

  2. NM_169395.2 → NP_731580.1  defective proboscis extension response 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INK5
    Related
    FBpp0081871
    Conserved Domains (3) summary
    cd00096
    Location:173 → 240
    Ig; Immunoglobulin domain
    smart00410
    Location:168 → 240
    IG_like; Immunoglobulin like
    pfam07686
    Location:57 → 153
    V-set; Immunoglobulin V-set domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8INK5 Q8INK5
Q961T8 Q961T8

Gene LinkOut

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