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Mrp4 Multidrug resistance protein 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41387, updated on 9-Dec-2024

Summary

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Official Symbol
Mrp4provided by FlyBase
Official Full Name
Multidrug resistance protein 4provided by FlyBase
Primary source
FLYBASE:FBgn0263316
Locus tag
Dmel_CG14709
See related
AllianceGenome:FB:FBgn0263316
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:CK01227; BEST:CK02472; CG14709; CK01227; DmCG14709; Dmel\CG14709; Dme_CG14709; dMrp4; dMRP4; EP3221; MRP4
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in several processes, including determination of adult lifespan; response to anoxia; and wing disc dorsal/ventral pattern formation. Predicted to be active in membrane. Is expressed in adult head; eye disc; larval central nervous system; larval ventral nerve cord; and photoreceptor neurons. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Mrp4 in Genome Data Viewer
Location:
86E11-86E11; 3-51 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11569250..11575937)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7394972..7401659)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fatty acid binding protein Neighboring gene scheggia Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene whacked

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila dMRP4 regulates responsiveness to O2 deprivation and development under hypoxia. Huang H, et al. Physiol Genomics, 2007 May 11. PMID 17284667
  2. Overexpression of SIRT3 Suppresses Oxidative Stress-induced Neurotoxicity and Mitochondrial Dysfunction in Dopaminergic Neuronal Cells. Lee S, et al. Exp Neurobiol, 2021 Oct 31. PMID 34737239, Free PMC Article
  3. Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Simcox AA, et al. Fly (Austin), 2008 Nov-Dec. PMID 19077546, Free PMC Article
  4. Modulation of oxidative stress resistance in Drosophila melanogaster by gene overexpression. Monnier V, et al. Genesis, 2002 Sep-Oct. PMID 12324953
  5. Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans. Zhou D, et al. Annu Rev Genomics Hum Genet, 2013. PMID 23808366

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to anoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multidrug resistance protein 4
Names
CG14709-PB
EP3221
Mrp4-PB
multidrug resistance protein 4 ortholog
NP_650086.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11569250..11575937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141829.3 → NP_650086.2  multidrug resistance protein 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650086.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8E786, Q9VGM1
    Conserved Domains (4) summary
    cd03244
    Location:1051 → 1272
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:422 → 622
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:12 → 1277
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:735 → 978
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGM1 Q9VGM1

Gene LinkOut

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