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CG14718 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41413, updated on 4-Jan-2025

Summary

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Official Symbol
CG14718provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037939
Locus tag
Dmel_CG14718
See related
AllianceGenome:FB:FBgn0037939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg14718; Dmel\CG14718
Summary
Predicted to enable mRNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in connective tissue cancer (multiple); essential tremor 4; and neurodegenerative disease (multiple). Orthologous to human FUS (FUS RNA binding protein) and TAF15 (TATA-box binding protein associated factor 15). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG14718 in Genome Data Viewer
Location:
86E16-86E16; 3-51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11700614..11702720)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7526336..7528442)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene 48 related 3 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46011 Neighboring gene inhibitor-t

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ephemeral association between gene CG5762 and hybrid male sterility in Drosophila sibling species. Ma D, et al. J Mol Evol, 2011 Oct. PMID 22052252
  2. Scrutinizing the human TEX genes in the context of human male infertility. Sieper MH, et al. Andrology, 2024 Mar. PMID 37594251
  3. Requirement of Split ends for epigenetic regulation of Notch signal-dependent genes during infection-induced hemocyte differentiation. Jin LH, et al. Mol Cell Biol, 2009 Mar. PMID 19139277, Free PMC Article
  4. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article
  5. spenito is required for sex determination in Drosophila melanogaster. Yan D, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26324914, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG14718-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11700614..11702720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141850.2 → NP_650107.1  uncharacterized protein Dmel_CG14718 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961N8, Q9VGJ3
    Related
    FBpp0081902, FBtr0082426
    Conserved Domains (5) summary
    COG0724
    Location:222 → 335
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    sd00025
    Location:343 → 362
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:343 → 366
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl02656
    Location:397 → 423
    zf-RanBP; Zn-finger in Ran binding protein and others
    cl17169
    Location:223 → 302
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VGJ3 Q9VGJ3

Gene LinkOut

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