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CG6923 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41420, updated on 4-Jan-2025

Summary

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Official Symbol
CG6923provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037944
Locus tag
Dmel_CG6923
See related
AllianceGenome:FB:FBgn0037944
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6923
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be active in cytosol. Is expressed in wing hinge primordium and wing pouch. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG6923 in Genome Data Viewer
Location:
86E17-86E17; 3-51 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11744229..11750029, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7569951..7575751, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bloom syndrome helicase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lk6 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development. Arquier N, et al. Curr Biol, 2005 Jan 11. PMID 15649359
  2. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
  3. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Molnar C, et al. Genetics, 2012 Oct. PMID 22798488, Free PMC Article
  4. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
  5. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6923-PA
CG6923-PB
CG6923-PC
CG6923-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11744229..11750029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141855.4 → NP_650112.1  uncharacterized protein Dmel_CG6923, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWE3, Q9VGI6
    Related
    FBpp0081908
    Conserved Domains (2) summary
    pfam12678
    Location:1185 → 1228
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:1187 → 1228
    zf-RING_2; Ring finger domain

  2. NM_001260127.1 → NP_001247056.1  uncharacterized protein Dmel_CG6923, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247056.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWE3, Q9VGI6
    Conserved Domains (2) summary
    pfam12678
    Location:1185 → 1228
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:1187 → 1228
    zf-RING_2; Ring finger domain

  3. NM_001275555.2 → NP_001262484.1  uncharacterized protein Dmel_CG6923, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262484.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFN6, Q6AWE3
    Conserved Domains (2) summary
    pfam12678
    Location:1185 → 1228
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:1187 → 1228
    zf-RING_2; Ring finger domain

  4. NM_169422.2 → NP_731623.1  uncharacterized protein Dmel_CG6923, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6AWE3, Q9VGI6
    Related
    FBpp0081909
    Conserved Domains (2) summary
    pfam12678
    Location:1185 → 1228
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:1187 → 1228
    zf-RING_2; Ring finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFN6 A0A0B4KFN6
Q9VGI6 Q9VGI6

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