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TRH thyrotropin releasing hormone [ Gallus gallus (chicken) ]

Gene ID: 414344, updated on 3-Dec-2024

Summary

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Symbol
TRHprovided by CGNC
Full Name
thyrotropin releasing hormoneprovided by CGNC
Primary source
CGNC:6439
See related
Ensembl:ENSGALG00010021890
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Pro-TRH
Orthologs
human mouse all
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Genomic context

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See TRH in Genome Data Viewer
Location:
chromosome: 12
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19868609..19893158)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (19906855..19931403)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene uncharacterized LOC121106672 Neighboring gene uncharacterized LOC107054396 Neighboring gene rabenosyn, RAB effector Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene nuclear receptor subfamily 2 group C member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of prepro-thyrotropin-releasing hormone in the chicken (Gallus gallus) and its expression in the brain. Aoki Y, et al. Zoolog Sci, 2007 Jul. PMID 17824776
  2. Cloning and hypothalamic distribution of the chicken thyrotropin-releasing hormone precursor cDNA. Vandenborne K, et al. J Endocrinol, 2005 Aug. PMID 16079264
  3. Effects of cold stress on the messenger ribonucleic acid levels of corticotrophin-releasing hormone and thyrotropin-releasing hormone in hypothalami of broilers. Wang JT, et al. Poult Sci, 2008 May. PMID 18420990
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The results indicate that the 2 genes show different response to cold stress at the mRNA levels, and on the other hand, the different degree of cold stress also produces different effects on the identical gene.
    Title: Effects of cold stress on the messenger ribonucleic acid levels of corticotrophin-releasing hormone and thyrotropin-releasing hormone in hypothalami of broilers.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables thyrotropin-releasing hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyrotropin releasing hormone
Names
prepro-thyrotropin-releasing hormone
pro-thyrotropin-releasing hormone
prothyroliberin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030383.2 → NP_001025554.1  thyrotropin releasing hormone preproprotein

    See identical proteins and their annotated locations for NP_001025554.1

    Status: VALIDATED

    Source sequence(s)
    AB205116, JAENSK010000252
    UniProtKB/Swiss-Prot
    Q5DW25, Q6ZXC3
    UniProtKB/TrEMBL
    A0A8V0ZMP9
    Related
    ENSGALP00010032089.1, ENSGALT00010053243.1
    Conserved Domains (1) summary
    pfam05438
    Location:16 → 227
    TRH; Thyrotropin-releasing hormone (TRH)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19868609..19893158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646169.2 → XP_040502103.1  thyrotropin releasing hormone isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZMP9

  2. XM_040646170.2 → XP_040502104.1  thyrotropin releasing hormone isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZMP9

  3. XM_040646165.2 → XP_040502099.1  thyrotropin releasing hormone isoform X1

    UniProtKB/Swiss-Prot
    Q5DW25, Q6ZXC3
    UniProtKB/TrEMBL
    A0A8V0ZMP9
    Conserved Domains (1) summary
    pfam05438
    Location:16 → 227
    TRH; Thyrotropin-releasing hormone (TRH)

  4. XM_040646171.2 → XP_040502105.1  thyrotropin releasing hormone isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZMP9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19906855..19931403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926187.1 → XP_046782143.1  thyrotropin releasing hormone isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZMP9

  2. XM_046926188.1 → XP_046782144.1  thyrotropin releasing hormone isoform X2

    UniProtKB/TrEMBL
    A0A8V0ZMP9

  3. XM_046926186.1 → XP_046782142.1  thyrotropin releasing hormone isoform X1

    UniProtKB/Swiss-Prot
    Q5DW25, Q6ZXC3
    UniProtKB/TrEMBL
    A0A8V0ZMP9

  4. XM_046926189.1 → XP_046782145.1  thyrotropin releasing hormone isoform X3

    UniProtKB/TrEMBL
    A0A8V0ZMP9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZXC3.2 GenPept UniProtKB/Swiss-Prot:Q6ZXC3

Gene LinkOut

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