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P4HA3 prolyl 4-hydroxylase subunit alpha 3 [ Bos taurus (domestic cattle) ]

Gene ID: 414348, updated on 27-Dec-2024

Summary

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Official Symbol
P4HA3provided by VGNC
Official Full Name
prolyl 4-hydroxylase subunit alpha 3provided by VGNC
Primary source
VGNC:VGNC:32537
See related
Ensembl:ENSBTAG00000006579
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See P4HA3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (53609484..53681795, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene C2 domain containing 3 centriole elongation regulator Neighboring gene cytochrome c oxidase subunit 6C-like Neighboring gene transfer RNA glutamic acid (anticodon UUC) Neighboring gene protein phosphatase methylesterase 1 Neighboring gene ribosomal protein L36a Neighboring gene phosphoglucomutase 2 like 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables L-ascorbic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables procollagen-proline 4-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prolyl 4-hydroxylase subunit alpha-3
Names
4-PH alpha-3
Collagen prolyl 4-hydroxylase alpha III subunit
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III
procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-3
NP_001001598.1
XP_024830814.1
XP_024830815.1
XP_024830816.1
XP_024830817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001598.2 → NP_001001598.1  prolyl 4-hydroxylase subunit alpha-3 precursor

    See identical proteins and their annotated locations for NP_001001598.1

    Status: PROVISIONAL

    Source sequence(s)
    AB126035
    UniProtKB/Swiss-Prot
    Q75UG4
    UniProtKB/TrEMBL
    A0AAF6YQ39
    Conserved Domains (3) summary
    smart00702
    Location:356 → 528
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:58 → 159
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    pfam13424
    Location:186 → 242
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    53609484..53681795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975047.2 → XP_024830815.1  prolyl 4-hydroxylase subunit alpha-3 isoform X2

    UniProtKB/TrEMBL
    A0AAA9RUF1, A0AAF6YQ39
    Related
    ENSBTAP00000075766.1, ENSBTAT00000117575.1
    Conserved Domains (2) summary
    smart00702
    Location:356 → 517
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:58 → 159
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  2. XM_024975046.2 → XP_024830814.1  prolyl 4-hydroxylase subunit alpha-3 isoform X1

    UniProtKB/TrEMBL
    A0AAF6YQ39
    Related
    ENSBTAP00000008644.6, ENSBTAT00000008644.7
    Conserved Domains (2) summary
    smart00702
    Location:356 → 517
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:58 → 159
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

  3. XM_024975049.2 → XP_024830817.1  prolyl 4-hydroxylase subunit alpha-3 isoform X4

    Conserved Domains (1) summary
    smart00702
    Location:216 → 377
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

  4. XM_024975048.2 → XP_024830816.1  prolyl 4-hydroxylase subunit alpha-3 isoform X3

    Conserved Domains (2) summary
    smart00702
    Location:248 → 409
    P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    pfam08336
    Location:2 → 51
    P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

RNA

  1. XR_237556.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75UG4.1 GenPept UniProtKB/Swiss-Prot:Q75UG4

Gene LinkOut

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