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Tk Tachykinin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41456, updated on 4-Jan-2025

Summary

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Official Symbol
Tkprovided by FlyBase
Official Full Name
Tachykininprovided by FlyBase
Primary source
FLYBASE:FBgn0037976
Locus tag
Dmel_CG14734
See related
AllianceGenome:FB:FBgn0037976
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14734; Dmel\CG14734; DmTK6; Drm-TK; Drm-TK-1; Drm-TK-2; Drm-TK-3; Drm-TK-4; Drm-TK-5; Drm-TK-6; dtk; dTK; Dtk; DTk; DTK; DTK-1; DTK-2; DTK-3; DTK-4; DTK-5; DTK-6; DTK1; Tachykinin 1; Tachykinin 2; Tachykinin 4; Tachykinin 5; TAP-5; TK; TK-1; Tyk
Summary
Enables tachykinin receptor binding activity. Involved in several processes, including adult walking behavior; inter-male aggressive behavior; and positive regulation of hindgut contraction. Located in extracellular space. Is expressed in several structures, including enteroendocrine cell; ganglia; neuromere; sexually-dimorphic neurons; and tachykinin neurons. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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Location:
87A4-87A4; 3-51 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11994175..12005473, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7819897..7831195, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene midline fasciclin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and functional characterization of a Drosophila neuropeptide precursor with homology to mammalian preprotachykinin A. Siviter RJ, et al. J Biol Chem, 2000 Jul 28. PMID 10801863
  2. Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila. Winther AM, et al. Mol Cell Neurosci, 2006 Mar. PMID 16289899
  3. Imaging neuropeptide release at synapses with a genetically engineered reporter. Ding K, et al. Elife, 2019 Jun 26. PMID 31241464, Free PMC Article
  4. Substitution of conserved glycine residue by alanine in natural and synthetic neuropeptide ligands causes partial agonism at the stomoxytachykinin receptor. Poels J, et al. J Neurochem, 2004 Jul. PMID 15228603
  5. Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila. Winther AM, et al. J Comp Neurol, 2003 Sep 15. PMID 12898611

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.
    Title: Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila.
  2. These results highlight a conserved role for Tachykinin signaling in regulating nociception.
    Title: Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila.
  3. Study identified a small group of sexually dimorphic, FruM+ neurons that promote aggressiveness in Drosophila males but have no influence on male-female courtship behavior. These neurons enhance aggression, at least in part, through the release of a neuropeptide, Drosophila tachykinin.
    Title: Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila.
  4. The control of DILP5 signaling in the renal tubules by Drosophila tachykinin peptide (DTK) and its receptor DTKR during desiccative, nutritional and oxidative stress, was investigated.
    Title: Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance.
  5. The distribution of the Dtk transcript and peptides was analyzed by in situ hybridization and immunocytochemistry during postembryonic development of the central nervous system (CNS) of Drosophila.
    Title: Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neuropeptide hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables signaling receptor binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables tachykinin receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult walking behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inter-male aggressive behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hindgut contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to pheromone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tachykinin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tachykinin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IC
Inferred by Curator
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tachykinin
Names
CG14734-PA
CG14734-PB
Tachykinin-related
Tk-PA
Tk-PB
neurokinin
preprotachykinin
tachykinin-1
tachykinin-3
tachykinin-6
tachykinin-like peptide

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11994175..12005473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275564.2 → NP_001262493.1  tachykinin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262493.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFT7

  2. NM_141884.4 → NP_650141.2  tachykinin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650141.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RJL9, Q8SZ21, Q9NBJ5, Q9VGE8
    Related
    FBpp0081962
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFT7 A0A0B4KFT7
Q9VGE8.1 Q9VGE8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
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