CDH5 cadherin 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CDH5provided by VGNC
Official Full Name: cadherin 5provided by VGNC
Primary source: VGNC:VGNC:97252
See related: Ensembl:ENSBTAG00000007421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	ARS-UCD2.0 (GCF_002263795.3)	18	NC_037345.1 (34122721..34159010)

Chromosome 18 - NC_037345.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Dominette sequence data
BioProject: PRJNA294306
Analysis date: Tue Dec 17 08:57:05 2024

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

VE-cadherin induces opposing growth signals.
Title: VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension.
In all, these results demonstrate that cell-cell contact signals through VE-cadherin, RhoA, and intracellular tension in the actin cytoskeleton to regulate proliferation.
Title: Engineering amount of cell-cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton.
exposure of BAECs to hydrostatic pressure (PHYSIOLOGIC PRESSURE) may downregulate the expression of VE-cadherin, resulting in loss of contact inhibition followed by increased proliferation and formation of a multilayered structure
Title: Hydrostatic pressure influences morphology and expression of VE-cadherin of vascular endothelial cells.
Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA
Title: Vascular endothelial-cadherin regulates cytoskeletal tension, cell spreading, and focal adhesions by stimulating RhoA.
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
Title: Integrins regulate VE-cadherin and catenins: dependence of this regulation on Src, but not on Ras.
investigated the role of catenin p120-VE-cadherin interaction in regulation of barrier function in confluent endothelial monolayers
Title: VE-cadherin-p120 interaction is required for maintenance of endothelial barrier function.
a VE-cadherin-dependent pathway may link T2-TrpRS to inhibition of new blood vessel formation
Title: VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cadherin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell-cell junction assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of establishment of cell polarity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasculature development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info	PubMed
part_of catenin complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: cadherin-5

Names: VE-cadherin; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); vascular endothelial cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001601.1 → NP_001001601.1 cadherin-5 precursor

Status: PROVISIONAL

Source sequence(s)

AY363224

UniProtKB/Swiss-Prot

Q6URK6

UniProtKB/TrEMBL

G3MZL1, G5E588

Related

ENSBTAP00000009760.6, ENSBTAT00000009760.7

Conserved Domains (3) summary

cd11304
Location:261 → 367

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:80 → 147

CA; Cadherin repeats

pfam01049
Location:633 → 774

Cadherin_C; Cadherin cytoplasmic region