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CDH6 cadherin 6 [ Gallus gallus (chicken) ]

Gene ID: 414842, updated on 17-Aug-2024

Summary

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Symbol
CDH6provided by CGNC
Full Name
cadherin 6provided by CGNC
Primary source
CGNC:9782
See related
Ensembl:ENSGALG00010011040
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
c-cad6B; cadherin-6; cadherin-6B
Orthologs
human mouse all
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Genomic context

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See CDH6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (68994007..69108464, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (68978296..69093058, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene melanocortin 4 receptor Neighboring gene C5orf22 Neighboring gene drosha ribonuclease III Neighboring gene uncharacterized LOC124417730 Neighboring gene uncharacterized LOC121109750 Neighboring gene uncharacterized LOC121109749

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation. Schiffmacher AT, et al. J Cell Biol, 2016 Dec 5. PMID 27856599, Free PMC Article
  2. Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT. Padmanabhan R, et al. J Cell Sci, 2015 May 1. PMID 25795298, Free PMC Article
  3. Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest. Schiffmacher AT, et al. Mol Biol Cell, 2014 Jan. PMID 24196837, Free PMC Article
  4. Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling. Park KS, et al. Dev Biol, 2012 Jun 15. PMID 22537493, Free PMC Article
  5. Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest. Park KS, et al. Development, 2010 Aug. PMID 20610481, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cad6B C-terminal fragments possesses a novel pro-epithelial-to-mesenchymal transition (EMT) role by up-regulating EMT effector genes in vivo.
    Title: Cadherin-6B proteolysis promotes the neural crest cell epithelial-to-mesenchymal transition through transcriptional regulation.
  2. Cad6B is removed from premigratory neural crest cells through cell surface internalization events that include clathrin-mediated endocytosis and macropinocytosis.
    Title: Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT.
  3. Knockdown or loss of function of Cadherin-6B suppressed the generation of Islet-1-expressing cells in the dorsal neural tube, but not the Lim-1/2 positive dorsal cell population.
    Title: Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons.
  4. A dual mechanism for Cad6B proteolysis involving two ADAMs, along with gamma-secretase, during cranial neural crest cell epithelial-to-mesenchymal transitions.
    Title: Cadherin-6B is proteolytically processed during epithelial-to-mesenchymal transitions of the cranial neural crest.
  5. these data reveal post-translational regulation of Cad6B protein levels by Tspan18 that must be relieved by a FoxD3-dependent mechanism in order for cranial neural crest cells to migrate.
    Title: Tetraspanin18 is a FoxD3-responsive antagonist of cranial neural crest epithelial-to-mesenchymal transition that maintains cadherin-6B protein.
  6. the de-epithelialization step of the neural crest epithelial mesenchymal transition by cadherin-6B involves regulation of actin dynamics via LIMK/cofilin
    Title: Cadherin-6B stimulates an epithelial mesenchymal transition and the delamination of cells from the neural ectoderm via LIMK/cofilin mediated non-canonical BMP receptor signaling.
  7. find that cadherin 6B persists in early migrating neural crest cells and is required for their emigration from the neural tube.
    Title: Cadherin 6B induces BMP signaling and de-epithelialization during the epithelial mesenchymal transition of the neural crest.
  8. Cad7 and Cad6B differentially regulate cranial motoneuron growth, branching and axon guidance.
    Title: Cadherin-7 and cadherin-6B differentially regulate the growth, branching and guidance of cranial motor axons.
  9. cadherin-6B was expressed in many song nuclei of the juvenile and adult brain.
    Title: Expression analysis of cadherins in the songbird brain: relationship to vocal system development.
  10. Cadherin6B is a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development.
    Title: Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest.
Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adherens junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cadherin-6
Names
cadherin 6, type 2, K-cadherin (fetal kidney)
cadherin 6B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001758.3 → NP_001001758.1  cadherin-6 isoform a precursor

    See identical proteins and their annotated locations for NP_001001758.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/Swiss-Prot
    Q90762
    Related
    ENSGALP00010015057.1, ENSGALT00010026451.1
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  2. NM_001397653.1 → NP_001384582.1  cadherin-6 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040

  3. NM_001397654.1 → NP_001384583.1  cadherin-6 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    68994007..69108464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919630.1 → XP_046775586.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762

  2. XM_040677344.2 → XP_040533278.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  3. XM_040677352.2 → XP_040533286.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  4. XM_025147082.3 → XP_025002850.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:637 → 783
    Cadherin_C; Cadherin cytoplasmic region

  5. XM_046919636.1 → XP_046775592.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762

  6. XM_046919635.1 → XP_046775591.1  cadherin-6 isoform X1

    UniProtKB/Swiss-Prot
    Q90762

  7. XM_040677378.2 → XP_040533312.1  cadherin-6 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:92 → 193
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:8 → 86
    CA; Cadherin repeats

  8. XM_040677399.1 → XP_040533333.1  cadherin-6 isoform X4

    Conserved Domains (1) summary
    cl29226
    Location:4 → 49
    Cadherin; Cadherin domain

  9. XM_040677389.2 → XP_040533323.1  cadherin-6 isoform X3

    Conserved Domains (2) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    68978296..69093058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910587.1 → XP_046766543.1  cadherin-6 isoform X1

  2. XM_046910586.1 → XP_046766542.1  cadherin-6 isoform X1

  3. XM_046910588.1 → XP_046766544.1  cadherin-6 isoform X1

  4. XM_046910589.1 → XP_046766545.1  cadherin-6 isoform X1

  5. XM_046910590.1 → XP_046766546.1  cadherin-6 isoform X1

  6. XM_046910591.1 → XP_046766547.1  cadherin-6 isoform X2

  7. XM_046910593.1 → XP_046766549.1  cadherin-6 isoform X4

  8. XM_046910592.1 → XP_046766548.1  cadherin-6 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90762.1 GenPept UniProtKB/Swiss-Prot:Q90762

Gene LinkOut

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