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rnf14 ring finger protein 14 [ Danio rerio (zebrafish) ]

Gene ID: 415177, updated on 4-Jan-2025

Summary

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Official Symbol
rnf14provided by ZNC
Official Full Name
ring finger protein 14provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-65
See related
Ensembl:ENSDARG00000043905 AllianceGenome:ZFIN:ZDB-GENE-040625-65
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86928; wu:fb80d11; wu:fi42d09
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Acts upstream of or within regulation of canonical Wnt signaling pathway. Predicted to be located in nucleus. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See rnf14 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (41839476..41862079)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (41826266..41848866)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transcription elongation regulator 1b (CA150) Neighboring gene chaperonin containing TCP1, subunit 6A (zeta 1) Neighboring gene endonuclease, polyU-specific 2 Neighboring gene gamma-aminobutyric acid type A receptor subunit gamma2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Embryonic atrazine exposure elicits proteomic, behavioral, and brain abnormalities with developmental time specific gene expression signatures. Horzmann KA, et al. J Proteomics, 2018 Aug 30. PMID 30012420, Free PMC Article
  2. Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival. Wu B, et al. EMBO Rep, 2013 Apr. PMID 23449499, Free PMC Article
  3. Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities. De Meulemeester AS, et al. Front Cell Dev Biol, 2022. PMID 36238691, Free PMC Article
  4. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein-RNA covalent cross-linking repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF14
Names
ARA54
NP_001002087.1
XP_005161507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002087.1 → NP_001002087.1  E3 ubiquitin-protein ligase RNF14

    See identical proteins and their annotated locations for NP_001002087.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071542
    UniProtKB/TrEMBL
    Q6IQ68
    Related
    ENSDARP00000017558.6, ENSDART00000010942.8
    Conserved Domains (3) summary
    smart00647
    Location:273 → 334
    IBR; In Between Ring fingers
    pfam01485
    Location:384 → 419
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:4 → 125
    RWD; RWD domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    41839476..41862079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005161450.4 → XP_005161507.1  E3 ubiquitin-protein ligase RNF14 isoform X1

    UniProtKB/Swiss-Prot
    A0A8M2B8B6, F1RB95, Q6IQ68
    Conserved Domains (3) summary
    smart00647
    Location:273 → 334
    IBR; In Between Ring fingers
    pfam01485
    Location:384 → 419
    IBR; IBR domain, a half RING-finger domain
    pfam05773
    Location:4 → 125
    RWD; RWD domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1RB95.1 GenPept UniProtKB/Swiss-Prot:F1RB95

Gene LinkOut

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