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Cyp9f2 Cytochrome P450 9f2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41520, updated on 12-Dec-2024

Summary

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Official Symbol
Cyp9f2provided by FlyBase
Official Full Name
Cytochrome P450 9f2provided by FlyBase
Primary source
FLYBASE:FBgn0038037
Locus tag
Dmel_CG11466
See related
AllianceGenome:FB:FBgn0038037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
9f2; anon-EST:Posey150; CG11466; Cyp 9f2; Cyp9F2; CYP9F2; Dmel\CG11466
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in wing disc development. Is expressed in adult head; adult heart; embryonic/larval midgut; epithelium; and yolk nucleus. Human ortholog(s) of this gene implicated in Ghosal hematodiaphyseal syndrome; cerebral infarction; essential hypertension; familial Mediterranean fever; and leukemia (multiple). Orthologous to several human genes including CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough); CYP3A4 (cytochrome P450 family 3 subfamily A member 4); and CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Cyp9f2 in Genome Data Viewer
Location:
87B9-87B9; 3-52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12403340..12406028, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8229062..8231750, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sol1 Neighboring gene Cytochrome P450 9f3 Neighboring gene DNA ligase 3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dibutyl Phthalate Exposure Disrupts Evolutionarily Conserved Insulin and Glucagon-Like Signaling in Drosophila Males. Williams MJ, et al. Endocrinology, 2016 Jun. PMID 27100621
  2. RNA interference validation of detoxification genes involved in ivermectin tolerance in Drosophila melanogaster. Kim JH, et al. Insect Mol Biol, 2018 Oct. PMID 29888824
  3. The involvement of cytochrome P450 monooxygenases in methanol elimination in Drosophila melanogaster larvae. Wang SP, et al. Arch Insect Biochem Physiol, 2012 Apr. PMID 22508581
  4. Hazardous effects of octopamine receptor agonists on altering metabolism-related genes and behavior of Drosophila melanogaster. Ahmed MAI, et al. Chemosphere, 2020 Aug. PMID 32283422, Free PMC Article
  5. Association of detoxification enzymes with butene-fipronil in larvae and adults of Drosophila melanogaster. Arain MS, et al. Environ Sci Pollut Res Int, 2018 Apr. PMID 29380196

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
cytochrome P450 9f2
Names
CG11466-PA
Cyp9f2-PA
cytochrome P450
NP_650189.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12403340..12406028 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141932.3 → NP_650189.1  cytochrome P450 9f2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VG82
    Related
    FBpp0082070
    Conserved Domains (1) summary
    pfam00067
    Location:36 → 510
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VG82.1 Q9VG82

Gene LinkOut

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