pps protein partner of snf [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ppsprovided by FlyBase
Official Full Name: protein partner of snfprovided by FlyBase
Primary source: FLYBASE:FBgn0082831
Locus tag: Dmel_CG6525
See related: AllianceGenome:FB:FBgn0082831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6525; Dmel\CG6525; FBgn0082831; PPS; spp; Spp; SPP
Summary: Involved in regulation of alternative mRNA splicing, via spliceosome. Located in chromatin. Part of small nuclear ribonucleoprotein complex. Is expressed in spermatozoon. Orthologous to several human genes including PHF3 (PHD finger protein 3) and DIDO1 (death inducer-obliterator 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 87B9-87B9; 3-52 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (12413828..12421251)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (8239550..8246973)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results identified a novel pH-dependent mechanism by which epigenetic reader, the PHD fingers of PPS, recognize the histone mark H3K4me3. The pH-sensing ability might be necessary for normal biological processes and those characterized by altered cellular pH.
Title: A Unique pH-Dependent Recognition of Methylated Histone H3K4 by PPS and DIDO.
These data indicate that PPS is different from other splicing factors involved in male-exon skipping and suggest, for the first time, a functional link between transcription and SXL-mediated alternative splicing.
Title: PPS, a large multidomain protein, functions with sex-lethal to regulate alternative splicing in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of small nuclear ribonucleoprotein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein partner of snf

Names: CG6525-PA; CG6525-PB; SNFs protein partner; pps-PA; pps-PB; protein partner of sans fille; protein partner of sans-fille

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

12413828..12421251

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260146.2 → NP_001247075.1 protein partner of snf, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247075.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K6G3

Conserved Domains (5) summary

smart00592
Location:1142 → 1186

BRK; domain in transcription and CHROMO domain helicases

COG5034
Location:827 → 965

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15552
Location:914 → 963

PHD_PHF3_like; PHD finger found in PHD finger protein 3 (PHF3), and death-inducer obliterator variants Dido1, Dido2, and Dido3

pfam07500
Location:1274 → 1396

TFIIS_M; Transcription factor S-II (TFIIS), central domain

pfam07744
Location:1623 → 1729

SPOC; SPOC domain
NM_141936.2 → NP_650193.1 protein partner of snf, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650193.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VG78

Related

FBpp0082058

Conserved Domains (5) summary

smart00592
Location:1140 → 1184

BRK; domain in transcription and CHROMO domain helicases

COG5034
Location:825 → 963

TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]

cd15552
Location:912 → 961

PHD_PHF3_like; PHD finger found in PHD finger protein 3 (PHF3), and death-inducer obliterator variants Dido1, Dido2, and Dido3

pfam07500
Location:1272 → 1394

TFIIS_M; Transcription factor S-II (TFIIS), central domain

pfam07744
Location:1621 → 1727

SPOC; SPOC domain