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CG5245 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41530, updated on 9-Dec-2024

Summary

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Official Symbol
CG5245provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038047
Locus tag
Dmel_CG5245
See related
AllianceGenome:FB:FBgn0038047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.611; Dmel\CG5245
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including ZNF254 (zinc finger protein 254); ZNF571 (zinc finger protein 571); and ZNF595 (zinc finger protein 595). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CG5245 in Genome Data Viewer
Location:
87B10-87B10; 3-52 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12429560..12431235)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8255282..8256957)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1 at 87B Neighboring gene N-acetylneuraminic acid synthase Neighboring gene uncharacterized protein Neighboring gene Proteasome alpha2 subunit Neighboring gene Activator of SUMO 1 Neighboring gene Spliceosome-ribosome linker protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genetic suppressor of two dominant temperature-sensitive lethal proteasome mutants of Drosophila melanogaster is itself a mutated proteasome subunit gene. Neuburger PJ, et al. Genetics, 2006 Jul. PMID 16648584, Free PMC Article
  2. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Stevaux O, et al. Cell Cycle, 2005 Sep. PMID 16082225
  3. Functional variants identify sex-specific genes and pathways in Alzheimer's Disease. Bourquard T, et al. Nat Commun, 2023 May 13. PMID 37179358, Free PMC Article
  4. A network model of the molecular organization of chromatin in Drosophila. van Bemmel JG, et al. Mol Cell, 2013 Feb 21. PMID 23438860
  5. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5245-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12429560..12431235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141940.3 → NP_650197.1  uncharacterized protein Dmel_CG5245 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650197.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VG72
    Related
    FBpp0082061
    Conserved Domains (3) summary
    COG5048
    Location:74 → 478
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:179 → 204
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VG72 Q9VG72

Gene LinkOut

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